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Review Article

白杨素综述：分子靶点、药理作用和生物药学等方面

卷 23, 期 4, 2022

发表于: 24 August, 2021

页: [420 - 436] 页: 17

弟呕挨: 10.2174/1389450122666210824141044

价格: $65

摘要

白杨素（一种类黄酮）已显示出各种有希望的药理活性，即。抗癌、抗糖尿病、免疫调节、抗抑郁和抗哮喘。此外，它对肝脏、大脑、肾脏和心脏等不同器官的各种毒素表现出潜在的保护作用。已经进行了大量研究来探索其可能的作用机制的可能目标。然而，由于其口服生物利用度差，其治疗应用受到限制。其生物利用度差的主要原因是其广泛的首过代谢。尚未全面讨论对白杨素及其相关分子靶点的药理学特性的批判性审查。因此，本工作的重点是深入了解负责白杨素药理作用的分子靶点。此外，首次制作了示意图来表示白杨素的综合药代动力学特性，这有助于了解其成功交付的生物制药方面。深入了解白杨素的生物药学特性将有助于采用合适的制剂方法来克服口服生物利用度差的问题。此外，它有助于研究白杨素与其他药物可能的药代动力学相互作用。因此，我们发现白杨素是一种具有多种治疗特性的神奇天然药物，通过深入了解分子靶点、药理作用和生物制药属性，可以利用其益处。

关键词: 白杨素，化学预防，抗癌，保护作用，抗抑郁，抗糖尿病，抗病毒，药代动力学

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