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General Review Article

天然化合物通过抗炎发挥抗抑郁作用的研究进展

卷 29, 期 5, 2022

发表于: 05 January, 2022

页: [934 - 956] 页: 23

弟呕挨: 10.2174/0929867328666210820115259

价格: $65

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摘要

抑郁症是一种常见的精神疾病，属于情绪障碍的范畴，对患者的健康和生活造成严重损害，而炎症被认为是导致抑郁症的重要因素之一。在这种情况下，通过使用具有抗炎和抗抑郁作用的天然化合物来探索可能的治疗方法可能很重要，但最近尚未对其进行系统评价。因此，本综述旨在系统梳理有关通过抗炎作用发挥抗抑郁作用机制的文献，并从几个炎症相关途径（即蛋白激酶B（ Akt) 通路、单胺类神经递质（5-羟色胺和去甲肾上腺素）（5-HT 和 NE）、结节样受体蛋白 3 (NLRP3) 炎性体、促炎细胞因子、神经营养因子或细胞因子信号通路），它们可能提供为抑郁症的潜在治疗提供有用的参考。

关键词: 抑郁症，抗炎药，NLRP3炎性体，促炎细胞因子，天然化合物，抗抑郁药

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