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当代肿瘤药物靶点

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Research Article

用菊苣提取物/黄豆苷元组合靶向 HIF-1α/Cav-1 通路在延缓肝细胞癌中发挥潜在作用

卷 21, 期 10, 2021

发表于: 11 August, 2021

页: [881 - 896] 页: 16

弟呕挨: 10.2174/1568009621666210811121120

价格: $65

摘要

菊苣提取物/大豆苷元联合靶向HIF-1α/Cav-1通路在延缓肝细胞癌中发挥潜在作用 背景:肝细胞癌(hepatellular carcinoma, HCC)是一种生长速度最快的实体癌，其特点是缺氧。缺氧诱导因子-1α (Hypoxia-inducible factor-1α， HIF-1α)是一种调节肿瘤增殖和转移的转录因子。它诱导膜表面糖蛋白Cav-1 (cav1)的表达，然后Cav-1在HCC中触发血管生成和转移。 目的:我们假设，利用天然抗氧化化合物如chicoric酸和Cav-1抑制剂DAZ靶向HIF-1α和Cav-1可能是一种有效的治疗HCC的方法。本研究旨在探讨标准化chicory leaf extract (SCLE)和DAZ通过调节HIF-1α和Cav-1对HCC大鼠的治疗作用。 方法:采用二乙基亚硝胺(DENA)诱导肝癌。诱导期结束后，四组(每组10只)分别给予SCLE、DAZ(两者联合)及索拉非尼治疗，均与未处理对照组比较。检测肝脏HIF-1α蛋白表达、Cav-1基因表达、血清AFP水平、肝组织VEGF、MMP-9含量、氧化应激标志物MDA和SOD含量。 结果:DAZ、SCLE及两者联合可显著下调HIF-1α、Cav-1的表达，从而抑制MMP-9、VEGF、肝脏含量。已经观察到，与单独治疗相比，联合治疗显示出协同效应。重要的是，联合治疗显示出比索拉非尼更有效的效果。 结论:本研究显示HIF-1α/Cav-1通路在肝细胞癌进展中的潜在作用，SCLE和DAZ通过调节该通路具有明显的延缓肝细胞癌的作用。

关键词: 肝细胞癌，二乙基亚硝胺，菊苣叶提取物，大豆苷元，缺氧诱导因子-1α，小窝蛋白-1。

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