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Review Article

营养抗氧化治疗糖尿病血管并发症的最新进展：综合综述

卷 29, 期 11, 2022

发表于: 10 August, 2021

页: [1920 - 1935] 页: 16

弟呕挨: 10.2174/0929867328666210810142527

价格: $65

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摘要

糖尿病(DM)和DM引起的血管并发症是重要的全球医疗保健问题，导致患者的生活质量下降。患者残疾和死亡的主要原因是快速进展的微血管和大血管疾病。目前，自由基氧化被认为是糖尿病及相关并发症发生的主要机制之一。在正常的生理条件下，自由基的水平和抗氧化防御能力是平衡的。然而，在慢性高血糖过程中，抗氧化防御系统和促氧化剂之间发生不平衡，可能引发过量自由基的形成，导致脂质过氧化的激活和剧毒自由基氧化产物的积累。这也伴随着糖尿病患者不同程度的胰岛素缺乏和胰岛素抵抗。在激活自由基生成的同时，抗氧化防御因子(超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶、谷胱甘肽还原酶、维生素C和E)的活性降低，糖尿病并发症加速。因此，我们推测抗氧化剂可能在糖尿病患者的治疗中发挥积极的作用，以预防糖尿病引起的血管并发症。然而，这一点还没有得到充分的研究。在这篇综述中，我们讨论了氧化应激诱导的糖尿病并发症的潜在机制，以及抗氧化剂在缓解dm诱导的血管并发症中的作用。

关键词: 抗氧化制剂，氧化应激，糖尿病血管并发症，糖尿病，线粒体，神经保护。

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