New Perspectives in Drug Delivery Systems for the Treatment of
Tuberculosis

Joandra   Maísa   da Silva Leite; Yuri    Basilio Gomes    Patriota; Mônica   Felts   de La Roca; José   Lamartine   Soares-Sobrinho
doi:10.2174/0929867328666210629154908
Abstract

Background: Tuberculosis is a chronic respiratory disease caused by Mycobacterium tuberculosis. The common treatment regimens of tuberculosis are lengthy with adverse side effects, low patient compliance, and antimicrobial resistance. Drug delivery systems (DDSs) can overcome these limitations.
Objective: This review aims to summarize the latest DDSs for the treatment of tuberculosis. In the first section, the main pharmacokinetic and pharmacodynamic challenges posed by the innate properties of the drugs are put forth. The second section elaborates on the use of DDS to overcome the disadvantages of the current treatment of tuberculosis.
Conclusion: We reviewed research articles published in the last 10 years. DDSs can improve the physicochemical properties of anti-tuberculosis drugs, improving solubility, stability, and bioavailability, with better control of drug release and can target alveolar macrophages. However, more pre-clinical studies and robust bio-relevant analyses are needed for DDSs to become a feasible option to treat patients and attract investors.
Keywords: Mycobacterium tuberculosis, tuberculosis treatment, drug delivery systems, nanotechnology, controlled drug release, pharmacological activity.
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DOI https://dx.doi.org/10.2174/0929867328666210629154908	Print ISSN 0929-8673
Publisher Name Bentham Science Publisher	Online ISSN 1875-533X
Current Medicinal Chemistry

New Perspectives in Drug Delivery Systems for the Treatment of Tuberculosis

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