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Review Article

铁凋亡：抗击癌症耐药性的可信赖盟友

卷 29, 期 1, 2022

发表于: 10 August, 2021

页: [41 - 55] 页: 15

弟呕挨: 10.2174/0929867328666210810115812

价格: $65

摘要

铁凋亡是一种铁依赖性、非凋亡细胞死亡机制，最近被提出作为癌症治疗的新方法。因其具有鲜明的特征及其独特的机制，所以提出了触发这种新发现的细胞死亡形式的潜在治疗益处。许多研究表明，凋亡途径通常在耐药细胞中失活，导致治疗失败。因此，需要替代策略来促进细胞死亡。越来越多的证据表明，耐药癌细胞对铁凋亡特别敏感。鉴于癌细胞比健康细胞消耗更多的铁，铁凋亡不仅是引发细胞死亡和逆转耐药性的绝佳替代品，而且还提供了治疗的选择性。本综述特别关注通过激活铁质形成途径来克服癌症中的药物耐药性，并汇集了相关的基于化疗和基于纳米治疗的研究，为研究人员提供了关于该机制在开发新型治疗策略中的潜在用途的观点。

关键词: 铁凋亡，擦除剂，癌症，耐药性，顺铂，纳米治疗。

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