摘要
背景:间变性淋巴瘤激酶ALK基因的融合与重排是导致多种癌症的重要原因,包括非小细胞肺癌(NSCLC)和间变性大细胞淋巴瘤(ALCL)。自从克唑替尼问世以来,很多ALK抑制剂相继问世,但每一代ALK抑制剂的致命缺陷是机体对药物的耐药性。因此,如何解决耐药问题成为ALK抑制剂应用开发的重要瓶颈。本文简要介绍了ALK抑制剂的耐药性和ALK抑制剂的修饰形式,为解决ALK抑制剂的耐药性和开发新一代ALK激酶抑制剂提供了理论依据。 方法:利用相关数据库查询相关文献,然后根据内容的相关性和前沿性进行筛选和选择。然后我们总结和分析合适的文章,整合和分类相关研究,最后根据主题写文章。 结果:本文从ALK耐药问题入手,先介绍ALK激酶的组成,再介绍ALK激酶抑制剂的耐药问题。后来介绍了克服ALK抗性的结构修饰,最后介绍了克服ALK抗性的方法。 结论:本文总结了 ALK 激酶抑制剂的耐药途径,并整合了为克服 ALK 耐药问题的结构修饰所做的努力,希望为下一代 ALK 激酶抑制剂的开发提供一些启示。
关键词: 非小细胞肺癌,间变性淋巴瘤激酶,ALK抑制剂,ALK耐药,ALK药物修饰,克服耐药。
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