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Review Article

与生物活性配体偶联以提高铂化合物抗癌活性的最新进展

卷 29, 期 15, 2022

发表于: 06 August, 2021

页: [2566 - 2601] 页: 36

弟呕挨: 10.2174/0929867328666210806110857

价格: $65

摘要

铂（Pt）药物，包括顺铂，广泛用于治疗实体瘤。尽管临床上取得了成功，但副作用和耐药性的发生代表了使用临床上可用的Pt药物的主要局限性。为了克服这些问题，已经设计和合成了各种衍生物。本文综述了Pt（II）和Pt（IV）配合物与生物活性配体的开发进展.Pt（II）和Pt（IV）复合物与靶向分子，临床上可用的药物和其他生物活性分子的开发是一个活跃的研究领域。即使没有一种报道的Pt衍生物被批准用于临床，许多这些化合物也表现出有希望的抗癌活性，并具有改进的药理学特征。因此，规划杂化化合物可以被认为是一种有前途的方法，可以改进可用的基于Pt的抗癌剂，并获得新的分子工具，以加深对癌症进展和耐药机制的了解。

关键词: 铂化合物，偶联物，杂化抗癌剂，肿瘤靶向，耐药性，顺铂。

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