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Current Medicinal Chemistry

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ISSN (Online): 1875-533X

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Review Article

Recent Progresses in Conjugation with Bioactive Ligands to Improve the Anticancer Activity of Platinum Compounds

Author(s): Marco Zuccolo, Noemi Arrighetti, Paola Perego* and Diego Colombo

Volume 29, Issue 15, 2022

Published on: 06 August, 2021

Page: [2566 - 2601] Pages: 36

DOI: 10.2174/0929867328666210806110857

Price: $65

Abstract

Platinum (Pt) drugs, including cisplatin, are widely used for the treatment of solid tumors. Despite the clinical success, side effects and occurrence of resistance represent major limitations to the use of clinically available Pt drugs. To overcome these problems, a variety of derivatives have been designed and synthetized. Here, we summarize the recent progress in the development of Pt(II) and Pt(IV) complexes with bioactive ligands. The development of Pt(II) and Pt(IV) complexes with targeting molecules, clinically available agents, and other bioactive molecules is an active field of research. Even if none of the reported Pt derivatives has been yet approved for clinical use, many of these compounds exhibit promising anticancer activities with an improved pharmacological profile. Thus, planning hybrid compounds can be considered as a promising approach to improve the available Pt-based anticancer agents and to obtain new molecular tools to deepen the knowledge of cancer progression and drug resistance mechanisms.

Keywords: Platinum compounds, conjugates, hybrid anticancer agents, tumor targeting, drug resistance, cisplatin.

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