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Review Article

DUXAP8：一种很有前途的 lncRNA，在癌症中具有致癌潜力

卷 29, 期 10, 2022

发表于: 26 July, 2021

页: [1677 - 1686] 页: 10

弟呕挨: 10.2174/0929867328666210726092020

价格: $65

摘要

背景：长链非编码 RNA (lncRNA) 影响了许多生物学过程，引起了极大的兴趣。 不仅如此，LncRNA DUXAP8 通过影响 miRNA、信号通路和癌基因的活性来介导肿瘤发生。 方法：通过阅读PubMed相关文章，总结出DUXAP8的功能。 结果：lncRNA DUXAP8 在大多数肿瘤中充当癌基因。 异常过表达与肿瘤的增殖、侵袭、迁移和抗自噬有关。 DUXAP8对Akt/mTOR信号通路发挥促进作用，促进肿瘤的发生。 此外，DUXAP8 影响 miRNA 和蛋白质的活性，显示出其作为人类癌症治疗靶点的巨大潜力。 结论：LncRNA DUXAP8已被确定为肿瘤不可或缺的治疗靶点，为临床提供治疗方案。

关键词: 长链非编码 RNA、DUXAP8、肿瘤发生、生物标志物、潜在治疗靶点、癌症。

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