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Anti-Infective Agents

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ISSN (Print): 2211-3525
ISSN (Online): 2211-3533

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Research Article

Screening of Phytochemicals from Curcuma Longa for their Inhibitory Activity on SARS-CoV-2: An In-Silico Study

Author(s): Preeya Negi, Lalita Das, Surya Prakash and Vaishali M. Patil*

Volume 20, Issue 1, 2022

Published on: 19 July, 2021

Article ID: e190721194860 Pages: 19

DOI: 10.2174/2211352519666210719090130

Price: $65

Abstract

Introduction: Natural products or phytochemicals have always been useful as effective therapeutics providing the lead for rational drug discovery approaches in specific to anti-viral therapeutics.

Methods: The ongoing pandemic caused by novel coronavirus has created a demand for effective therapeutics. Thus, to achieve the primary objective to search for effective anti-viral therapeutics, in silico screening of phytochemicals present in the extract of Curcuma longa (ex. Curcumin) has been planned.

Results: The present work involves the evaluation of ADME properties and molecular docking studies.

Conclusion: The application of rationalized drug discovery approaches to screen the diverse natural resources will speed up the anti-COVID drug discovery efforts and benefit the global community.

Keywords: Cefoxitin, CoNS, disc, methicillin resistance, microdilution, VITEK 2.

Graphical Abstract

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