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Current Medical Imaging

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ISSN (Print): 1573-4056
ISSN (Online): 1875-6603

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Case Report

Gangliocytic Paraganglioma of the Gastrointestinal Tract: A Case Report of Cecal Origin

Author(s): Geojeong Seo, Jinyoung Park*, Eunjoo Lee, Jiyeon Han, Dasom Kim, Donghyun Kim, Jungwon Park, Minha Kwag and Soojin Jung

Volume 18, Issue 1, 2022

Published on: 16 July, 2021

Article ID: e160721194856 Pages: 4

DOI: 10.2174/1573405617666210716164040

Price: $65

Abstract

Introduction: Gangliocytic paraganglioma is an extremely rare tumor that is composed of epithelioid, ganglion, and spindle cells. It has a predilection site in the duodenum, especially the periampullary region. The clinical course is usually benign, but a few cases of metastasis to lymph nodes or distant sites have been noted. Several case reports or small series reviews of gangliocytic paraganglioma have been published, but so far, cecal gangliocytic paraganglioma has not been described.

Case Description: A 61-year-old man underwent an abdominal Computed Tomography (CT) scan for known GB stones, which revealed an incidental cecal mass. The patient underwent wedge resection of the cecum for diagnostic and therapeutic purposes. Histopathological examination of the cecal mass identified a gangliocytic paraganglioma. There was no evidence of metastasis in the dissected regional lymph nodes. No additional treatment, such as adjuvant chemotherapy or radiotherapy, was administered, and the patient underwent regular follow-up without any complications.

Conclusion: The most common radiologic finding in gangliocytic paraganglioma is a circumscribed, enhancing subepithelial mass. Herein, we report an uncommon case of cecal-origin gangliocytic paraganglioma. With knowledge of the radiologic and histologic characteristics of gangliocytic paraganglioma, appropriate management can be provided without unnecessary radical resection.

Keywords: Gangliocytic paraganglioma, neuroendocrine tumor, gastrointestinal tract, paraganglioma, gangliocytic paraganglioma CT, gangliocytic paraganglioma MR.

Graphical Abstract

[1]
Dahl EV, Waugh JM, Dahlin DC. Gastrointestinal ganglioneuromas; brief review with report of a duodenal ganglioneuroma. Am J Pathol 1957; 33(5): 953-65.
[PMID: 13458330]
[2]
Taylor HB, Helwig EB. Benign nonchromaffin paragangliomas of the duodenum. Virchows Arch Pathol Anat Physiol Klin Med 1962; 335: 356-66.
[http://dx.doi.org/10.1007/BF00957029] [PMID: 13919963]
[3]
Kepes JJ, Zacharias DL. Gangliocytic paragangliomas of the duodenum. A report of two cases with light and electron microscopic examination. Cancer 1971; 27(1): 61-7.
[http://dx.doi.org/10.1002/1097-0142(197101)27:1<61::AID-CNCR2820270111>3.0.CO;2-I] [PMID: 4099700]
[4]
Okubo Y, Yoshioka E, Suzuki M, et al. Diagnosis, pathological findings, and clinical management of gangliocytic paraganglioma: A systematic review. Front Oncol 2018; 8: 291.
[http://dx.doi.org/10.3389/fonc.2018.00291] [PMID: 30101131]
[5]
Dante S, Viale G, Dalla Palma P. Gangliocytic paraganglioma of the duodenum: Case report. Tumori 1987; 73(4): 425-9.
[http://dx.doi.org/10.1177/030089168707300419] [PMID: 2444023]
[6]
Hironaka M, Fukayama M, Takayashiki N, Saito K, Sohara Y, Funata N. Pulmonary gangliocytic paraganglioma: Case report and comparative immunohistochemical study of related neuroendocrine neoplasms. Am J Surg Pathol 2001; 25(5): 688-93.
[http://dx.doi.org/10.1097/00000478-200105000-00020] [PMID: 11342785]
[7]
Mann CM, Bramhall SR, Buckels JA, Taniere P. An unusual case of duodenal obstruction-gangliocytic paraganglioma. J Hepatobiliary Pancreat Surg 2009; 16(4): 562-5.
[http://dx.doi.org/10.1007/s00534-009-0092-8] [PMID: 19517054]
[8]
Ogata S, Horio T, Sugiura Y, Aiko S, Aida S. Duodenal gangliocytic paraganglioma with regional lymph node metastasis and a glandular component. Pathol Int 2011; 61(2): 104-7.
[http://dx.doi.org/10.1111/j.1440-1827.2010.02620.x] [PMID: 21255188]
[9]
Plaza JA, Vitellas K, Marsh WL Jr. Duodenal gangliocytic paraganglioma: A radiological-pathological correlation. Ann Diagn Pathol 2005; 9(3): 143-7.
[http://dx.doi.org/10.1016/j.anndiagpath.2005.02.004] [PMID: 15944956]
[10]
Buetow PC, Levine MS, Buck JL, Pantongrag-Brown L, Emory TS. Duodenal gangliocytic paraganglioma: CT, MR imaging, and US findings. Radiology 1997; 204(3): 745-7.
[http://dx.doi.org/10.1148/radiology.204.3.9280253] [PMID: 9280253]
[11]
Park HK, Han HS. Duodenal Gangliocytic paraganglioma with lymph node metastasis. Arch Pathol Lab Med 2016; 140(1): 94-8.
[http://dx.doi.org/10.5858/arpa.2014-0456-RS] [PMID: 26717062]
[12]
Wong A, Miller AR, Metter J, Thomas CR Jr. Locally advanced duodenal gangliocytic paraganglioma treated with adjuvant radiation therapy: Case report and review of the literature. World J Surg Oncol 2005; 3(1): 15.
[http://dx.doi.org/10.1186/1477-7819-3-15] [PMID: 15740625]

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