Environmental Factors Modifying HDL Functionality

doi:10.2174/0929867328666210714155422
摘要

背景：目前，人们已经认识到高密度脂蛋白(HDL)功能在保护动脉粥样硬化方面比循环HDL胆固醇(HDL-C)水平本身发挥更重要的作用。从巨噬细胞到高密度脂蛋白的胆固醇外排能力(CEC)已被证明是衡量高密度脂蛋白功能的一个关键指标。因此，CEC的定量评估可能是评估HDL功能的一个重要工具，因为HDL功能的改善可能导致降低心血管疾病(CVD)的风险。简介：虽然HDL的心脏保护作用主要通过参与其胆固醇反向转运(RCT)途径发挥作用，但HDL也具有重要的抗炎、抗氧化、抗聚集和抗凝特性，有助于其良好的心血管作用。某些遗传、病理生理、疾病状态和环境条件可能通过诱导脂质组和/或蛋白质组成的修饰，或诱导负责高密度脂蛋白代谢的酶的修饰，来影响高密度脂蛋白的心脏保护作用。另一方面，某些健康的习惯或药物干预实际上可能会有益地影响高密度脂蛋白的功能。方法：本文综述了肥胖、吸烟、饮酒、饮食习惯、各种药物干预、有氧运动等环境因素对高密度脂蛋白功能的影响。结果：实验和临床研究或药物干预支持这些环境因素对高密度脂蛋白功能改变的影响，尽管其相关机制尚未完全了解。结论：需要进一步研究确定这些环境因素的潜在机制，并确定能够增强CEC、改善HDL功能和潜在改善心血管风险的新的药物干预措施。
关键词: 高密度脂蛋白功能、胆固醇外排能力(CEC)、肥胖、吸烟、酒精、饮食习惯、药物干预、有氧运动。
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DOI https://dx.doi.org/10.2174/0929867328666210714155422	Print ISSN 0929-8673
Publisher Name Bentham Science Publisher	Online ISSN 1875-533X
当代药物化学

改变 HDL 功能的环境因素

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当代药物化学

改变 HDL 功能的环境因素

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