FTO在肿瘤中的作用及其研究进展

Robbens, S.; Rouzé, P.; Cock, J.M.; Spring, J.; Worden, A.Z.; Van de Peer, Y. The FTO gene, implicated in human obesity, is found only in vertebrates and marine algae. J. Mol. Evol., 2008, 66(1), 80-84.
[http://dx.doi.org/10.1007/s00239-007-9059-z] [PMID: 18058156]

Dina, C.; Meyre, D.; Gallina, S.; Durand, E.; Körner, A.; Jacobson, P.; Carlsson, L.M.; Kiess, W.; Vatin, V.; Lecoeur, C.; Delplanque, J.; Vaillant, E.; Pattou, F.; Ruiz, J.; Weill, J.; Levy-Marchal, C.; Horber, F.; Potoczna, N.; Hercberg, S.; Le Stunff, C.; Bougnères, P.; Kovacs, P.; Marre, M.; Balkau, B.; Cauchi, S.; Chèvre, J.C.; Froguel, P. Variation in FTO contributes to childhood obesity and severe adult obesity. Nat. Genet., 2007, 39(6), 724-726.
[http://dx.doi.org/10.1038/ng2048] [PMID: 17496892]

Scuteri, A.; Sanna, S.; Chen, W.M.; Uda, M.; Albai, G.; Strait, J.; Najjar, S.; Nagaraja, R.; Orrú, M.; Usala, G.; Dei, M.; Lai, S.; Maschio, A.; Busonero, F.; Mulas, A.; Ehret, G.B.; Fink, A.A.; Weder, A.B.; Cooper, R.S.; Galan, P.; Chakravarti, A.; Schlessinger, D.; Cao, A.; Lakatta, E.; Abecasis, G.R. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. PLoS Genet., 2007, 3(7)e115
[http://dx.doi.org/10.1371/journal.pgen.0030115] [PMID: 17658951]

Zhang, G.; Karns, R.; Narancic, N.S.; Sun, G.; Cheng, H.; Missoni, S.; Durakovic, Z.; Rudan, P.; Chakraborty, R.; Deka, R. Common SNPs in FTO gene are associated with obesity related anthropometric traits in an island population from the eastern Adriatic coast of Croatia. PLoS One, 2010, 5(4)e10375
[http://dx.doi.org/10.1371/journal.pone.0010375] [PMID: 20442772]

Chen, J.; Du, B. Novel positioning from obesity to cancer: FTO, an m6A RNA demethylase, regulates tumour progression. J. Cancer Res. Clin. Oncol., 2019, 145(1), 19-29.
[http://dx.doi.org/10.1007/s00432-018-2796-0] [PMID: 30465076]

Frayling, T.M.; Timpson, N.J.; Weedon, M.N.; Zeggini, E.; Freathy, R.M.; Lindgren, C.M.; Perry, J.R.; Elliott, K.S.; Lango, H.; Rayner, N.W.; Shields, B.; Harries, L.W.; Barrett, J.C.; Ellard, S.; Groves, C.J.; Knight, B.; Patch, A.M.; Ness, A.R.; Ebrahim, S.; Lawlor, D.A.; Ring, S.M.; Ben-Shlomo, Y.; Jarvelin, M.R.; Sovio, U.; Bennett, A.J.; Melzer, D.; Ferrucci, L.; Loos, R.J.; Barroso, I.; Wareham, N.J.; Karpe, F.; Owen, K.R.; Cardon, L.R.; Walker, M.; Hitman, G.A.; Palmer, C.N.; Doney, A.S.; Morris, A.D.; Smith, G.D.; Hattersley, A.T.; McCarthy, M.I. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science, 2007, 316(5826), 889-894.
[http://dx.doi.org/10.1126/science.1141634] [PMID: 17434869]

Kang, Y.; Liu, F.; Liu, Y. Is FTO gene variant related to cancer risk independently of adiposity? An updated meta-analysis of 129,467 cases and 290,633 controls. Oncotarget, 2017, 8(31), 50987-50996.
[http://dx.doi.org/10.18632/oncotarget.16446] [PMID: 28881622]

Han, Z.; Niu, T.; Chang, J.; Lei, X.; Zhao, M.; Wang, Q.; Cheng, W.; Wang, J.; Feng, Y.; Chai, J. Crystal structure of the FTO protein reveals basis for its substrate specificity. Nature, 2010, 464(7292), 1205-1209.
[http://dx.doi.org/10.1038/nature08921] [PMID: 20376003]

Wei, W.; Ji, X.; Guo, X.; Ji, S. Regulatory role of N6-methyladenosine(m6A)methylation in RNA processing and human diseases. J. Cell. Biochem., 2017, 118(9), 2534-2543.
[http://dx.doi.org/10.1002/jcb.25967] [PMID: 28256005]

Huang, W.; Qi, C.B.; Lv, S.W.; Xie, M.; Feng, Y.Q.; Huang, W.H.; Yuan, B.F. Determination of DNA and RNA methylation in circulating tumor cells by mass spectrometry. Anal. Chem., 2016, 88(2), 1378-1384.
[http://dx.doi.org/10.1021/acs.analchem.5b03962] [PMID: 26707930]

Fischer, J.; Koch, L.; Emmerling, C.; Vierkotten, J.; Peters, T.; Brüning, J.C.; Rüther, U. Inactivation of the Fto gene protects from obesity. Nature, 2009, 458(7240), 894-898.
[http://dx.doi.org/10.1038/nature07848] [PMID: 19234441]

Pischon, T.; Nöthlings, U.; Boeing, H. Obesity and cancer. Proc. Nutr. Soc., 2008, 67(2), 128-145.
[http://dx.doi.org/10.1017/S0029665108006976] [PMID: 18412987]

Cui, Q.; Shi, H.; Ye, P.; Li, L.; Qu, Q.; Sun, G.; Sun, G.; Lu, Z.; Huang, Y.; Yang, C.G.; Riggs, A.D.; He, C.; Shi, Y. m6A RNA methylation regulates the self-renewal and tumorigenesis of glioblastoma stem cells. Cell Rep., 2017, 18(11), 2622-2634.
[http://dx.doi.org/10.1016/j.celrep.2017.02.059] [PMID: 28297667]

Tang, H.; Dong, X.; Hassan, M.; Abbruzzese, J.L.; Li, D. Body mass index and obesity- and diabetes-associated genotypes and risk for pancreatic cancer. Cancer Epidemiol. Biomarkers Prev., 2011, 20(5), 779-792.
[http://dx.doi.org/10.1158/1055-9965.EPI-10-0845] [PMID: 21357378]

Chorley, B.N.; Wang, X.; Campbell, M.R.; Pittman, G.S.; Noureddine, M.A.; Bell, D.A. Discovery and verification of functional single nucleotide polymorphisms in regulatory genomic regions: current and developing technologies. Mutat. Res., 2008, 659(1-2), 147-157.
[http://dx.doi.org/10.1016/j.mrrev.2008.05.001] [PMID: 18565787]

Li, Z.; Weng, H.; Su, R.; Weng, X.; Zuo, Z.; Li, C.; Huang, H.; Nachtergaele, S.; Dong, L.; Hu, C.; Qin, X.; Tang, L.; Wang, Y.; Hong, G.M.; Huang, H.; Wang, X.; Chen, P.; Gurbuxani, S.; Arnovitz, S.; Li, Y.; Li, S.; Strong, J.; Neilly, M.B.; Larson, R.A.; Jiang, X.; Zhang, P.; Jin, J.; He, C.; Chen, J. FTO plays an oncogenic role in acute myeloid leukemia as a N6-Methyladenosine RNA Demethylase. Cancer Cell, 2017, 31(1), 127-141.
[http://dx.doi.org/10.1016/j.ccell.2016.11.017] [PMID: 28017614]

Bayraktar, S.; Rocha-Lima, C.M. Advanced or metastatic pancreatic cancer: Molecular targeted therapies. Mt. Sinai J. Med., 2010, 77(6), 606-619.
[http://dx.doi.org/10.1002/msj.20217] [PMID: 21105124]

Tang, X.; Liu, S.; Chen, D.; Zhao, Z.; Zhou, J. The role of the fat mass and obesity-associated protein in the proliferation of pancreatic cancer cells. Oncol. Lett., 2019, 17(2), 2473-2478.
[PMID: 30719115]

Zhao, L.; Zhou, J. Study on the function of fat mass and obesity-associated protein in pancreatic cancer cell. Xiandai Yixue, 2017, 45(12), 1781-1786.

Zeng, X.; Ban, Z.; Cao, J.; Zhang, W.; Chu, T.; Lei, D.; Du, Y. Association of FTO mutations with risk and survival of breast cancer in a chinese population. Dis. Markers, 2015, 2015101032
[http://dx.doi.org/10.1155/2015/101032] [PMID: 26146447]

Niu, Y.; Lin, Z.; Wan, A.; Chen, H.; Liang, H.; Sun, L.; Wang, Y.; Li, X.; Xiong, X.F.; Wei, B.; Wu, X.; Wan, G. RNA N6-methyladenosine demethylase FTO promotes breast tumor progression through inhibiting BNIP3. Mol. Cancer, 2019, 18(1), 46.
[http://dx.doi.org/10.1186/s12943-019-1004-4] [PMID: 30922314]

Tan, A.; Dang, Y.; Chen, G.; Mo, Z. Overexpression of the fat mass and obesity associated gene (FTO) in breast cancer and its clinical implications. Int. J. Clin. Exp. Pathol., 2015, 8(10), 13405-13410.
[PMID: 26722548]

Michailidou, K.; Hall, P.; Gonzalez-Neira, A.; Ghoussaini, M.; Dennis, J.; Milne, R.L.; Schmidt, M.K.; Chang-Claude, J.; Bojesen, S.E.; Bolla, M.K.; Wang, Q.; Dicks, E.; Lee, A.; Turnbull, C.; Rahman, N.; Fletcher, O.; Peto, J.; Gibson, L.; Dos Santos Silva, I.; Nevanlinna, H.; Muranen, T.A.; Aittomäki, K.; Blomqvist, C.; Czene, K.; Irwanto, A.; Liu, J.; Waisfisz, Q.; Meijers-Heijboer, H.; Adank, M.; van der Luijt, R.B.; Hein, R.; Dahmen, N.; Beckman, L.; Meindl, A.; Schmutzler, R.K.; Müller-Myhsok, B.; Lichtner, P.; Hopper, J.L.; Southey, M.C.; Makalic, E.; Schmidt, D.F.; Uitterlinden, A.G.; Hofman, A.; Hunter, D.J.; Chanock, S.J.; Vincent, D.; Bacot, F.; Tessier, D.C.; Canisius, S.; Wessels, L.F.; Haiman, C.A.; Shah, M.; Luben, R.; Brown, J.; Luccarini, C.; Schoof, N.; Humphreys, K.; Li, J.; Nordestgaard, B.G.; Nielsen, S.F.; Flyger, H.; Couch, F.J.; Wang, X.; Vachon, C.; Stevens, K.N.; Lambrechts, D.; Moisse, M.; Paridaens, R.; Christiaens, M.R.; Rudolph, A.; Nickels, S.; Flesch-Janys, D.; Johnson, N.; Aitken, Z.; Aaltonen, K.; Heikkinen, T.; Broeks, A.; Veer, L.J.; van der Schoot, C.E.; Guénel, P.; Truong, T.; Laurent-Puig, P.; Menegaux, F.; Marme, F.; Schneeweiss, A.; Sohn, C.; Burwinkel, B.; Zamora, M.P.; Perez, J.I.; Pita, G.; Alonso, M.R.; Cox, A.; Brock, I.W.; Cross, S.S.; Reed, M.W.; Sawyer, E.J.; Tomlinson, I.; Kerin, M.J.; Miller, N.; Henderson, B.E.; Schumacher, F.; Le Marchand, L.; Andrulis, I.L.; Knight, J.A.; Glendon, G.; Mulligan, A.M.; Lindblom, A.; Margolin, S.; Hooning, M.J.; Hollestelle, A.; van den Ouweland, A.M.; Jager, A.; Bui, Q.M.; Stone, J.; Dite, G.S.; Apicella, C.; Tsimiklis, H.; Giles, G.G.; Severi, G.; Baglietto, L.; Fasching, P.A.; Haeberle, L.; Ekici, A.B.; Beckmann, M.W.; Brenner, H.; Müller, H.; Arndt, V.; Stegmaier, C.; Swerdlow, A.; Ashworth, A.; Orr, N.; Jones, M.; Figueroa, J.; Lissowska, J.; Brinton, L.; Goldberg, M.S.; Labrèche, F.; Dumont, M.; Winqvist, R.; Pylkäs, K.; Jukkola-Vuorinen, A.; Grip, M.; Brauch, H.; Hamann, U.; Brüning, T.; Radice, P.; Peterlongo, P.; Manoukian, S.; Bonanni, B.; Devilee, P.; Tollenaar, R.A.; Seynaeve, C.; van Asperen, C.J.; Jakubowska, A.; Lubinski, J.; Jaworska, K.; Durda, K.; Mannermaa, A.; Kataja, V.; Kosma, V.M.; Hartikainen, J.M.; Bogdanova, N.V.; Antonenkova, N.N.; Dörk, T.; Kristensen, V.N.; Anton-Culver, H.; Slager, S.; Toland, A.E.; Edge, S.; Fostira, F.; Kang, D.; Yoo, K.Y.; Noh, D.Y.; Matsuo, K.; Ito, H.; Iwata, H.; Sueta, A.; Wu, A.H.; Tseng, C.C.; Van Den Berg, D.; Stram, D.O.; Shu, X.O.; Lu, W.; Gao, Y.T.; Cai, H.; Teo, S.H.; Yip, C.H.; Phuah, S.Y.; Cornes, B.K.; Hartman, M.; Miao, H.; Lim, W.Y.; Sng, J.H.; Muir, K.; Lophatananon, A.; Stewart-Brown, S.; Siriwanarangsan, P.; Shen, C.Y.; Hsiung, C.N.; Wu, P.E.; Ding, S.L.; Sangrajrang, S.; Gaborieau, V.; Brennan, P.; McKay, J.; Blot, W.J.; Signorello, L.B.; Cai, Q.; Zheng, W.; Deming-Halverson, S.; Shrubsole, M.; Long, J.; Simard, J.; Garcia-Closas, M.; Pharoah, P.D.; Chenevix-Trench, G.; Dunning, A.M.; Benitez, J.; Easton, D.F. Large-scale genotyping identifies 41 new loci associated with breast cancer risk. Nat. Genet., 2013, 45(4), 353-361, e1-e2.,
[http://dx.doi.org/10.1038/ng.2563] [PMID: 23535729]

Kaklamani, V.; Yi, N.; Sadim, M.; Siziopikou, K.; Zhang, K.; Xu, Y.; Tofilon, S.; Agarwal, S.; Pasche, B.; Mantzoros, C. The role of the fat mass and obesity associated gene (FTO) in breast cancer risk. BMC Med. Genet., 2011, 12, 52.
[http://dx.doi.org/10.1186/1471-2350-12-52] [PMID: 21489227]

Mojaver, M.; Mokarian, F.; Kazemi, M.; Salehi, M. Specific TaqMan allelic discrimination assay for rs1477196 and rs9939609 single nucleotide polymorphisms of FTO gene demonstrated that there is no association between these SNPs and risk of breast cancer in Iranian women. Adv. Biomed. Res., 2015, 4, 136.
[http://dx.doi.org/10.4103/2277-9175.161532] [PMID: 26322284]

Zhang, B.; Li, Y.; Li, L.; Chen, M.; Zhang, C.; Zuo, X.B.; Zhou, F.S.; Liang, B.; Zhu, J.; Li, P.; Huang, Z.L.; Xuan, H.; Li, W.; Chen, Z.D. Association study of susceptibility loci with specific breast cancer subtypes in Chinese women. Breast Cancer Res. Treat., 2014, 146(3), 503-514.
[http://dx.doi.org/10.1007/s10549-014-3041-4] [PMID: 25007960]

McGuire, S. World Cancer Report 2014. Geneva, Switzerland: World Health Organization, International Agency for Research on Cancer, WHO Press, 2015. Adv. Nutr., 2016, 7(2), 418-419.
[http://dx.doi.org/10.3945/an.116.012211] [PMID: 26980827]

Climent, M.; Hidalgo, N.; Vidal, Ó.; Puig, S.; Iglesias, M.; Cuatrecasas, M.; Ramón, J.M.; García-Albéniz, X.; Grande, L.; Pera, M. Postoperative complications do not impact on recurrence and survival after curative resection of gastric cancer. Eur. J. Surg. Oncol., 2016, 42(1), 132-139.
[http://dx.doi.org/10.1016/j.ejso.2015.08.163] [PMID: 26385054]

Jackson, C.B.; Giraud, A.S. STAT3 as a prognostic marker in human gastric cancer. J. Gastroenterol. Hepatol., 2009, 24(4), 505-507.
[http://dx.doi.org/10.1111/j.1440-1746.2009.05822.x] [PMID: 19368630]

Xu, D.; Shao, W.; Jiang, Y.; Wang, X.; Liu, Y.; Liu, X. FTO expression is associated with the occurrence of gastric cancer and prognosis. Oncol. Rep., 2017, 38(4), 2285-2292.
[http://dx.doi.org/10.3892/or.2017.5904] [PMID: 28849183]

Li, Y.; Zheng, D.; Wang, F.; Xu, Y.; Yu, H.; Zhang, H. Expression of demethylase genes, FTO and ALKBH1, is associated with prognosis of gastric cancer. Dig. Dis. Sci., 2019, 64(6), 1503-1513.
[http://dx.doi.org/10.1007/s10620-018-5452-2] [PMID: 30637548]

Hirsch, F.R.; Suda, K.; Wiens, J.; Bunn, P.A., Jr New and emerging targeted treatments in advanced non-small-cell lung cancer. Lancet, 2016, 388(10048), 1012-1024.
[http://dx.doi.org/10.1016/S0140-6736(16)31473-8] [PMID: 27598681]

Nicholson, B.; Suresh Kumar, K.G. The multifaceted roles of USP7: New therapeutic opportunities. Cell Biochem. Biophys., 2011, 60(1-2), 61-68.
[http://dx.doi.org/10.1007/s12013-011-9185-5] [PMID: 21468693]

Li, J.; Han, Y.; Zhang, H.; Qian, Z.; Jia, W.; Gao, Y.; Zheng, H.; Li, B. The m6A demethylase FTO promotes the growth of lung cancer cells by regulating the m6A level of USP7 mRNA. Biochem. Biophys. Res. Commun., 2019, 512(3), 479-485.
[http://dx.doi.org/10.1016/j.bbrc.2019.03.093] [PMID: 30905413]

Liu, J.; Ren, D.; Du, Z.; Wang, H.; Zhang, H.; Jin, Y. m6A demethylase FTO facilitates tumor progression in lung squamous cell carcinoma by regulating MZF1 expression. Biochem. Biophys. Res. Commun., 2018, 502(4), 456-464.
[http://dx.doi.org/10.1016/j.bbrc.2018.05.175] [PMID: 29842885]

Chan, S. A review of selective estrogen receptor modulators in the treatment of breast and endometrial cancer. Semin. Oncol., 2002, 29(3)(Suppl. 11), 129-133.
[http://dx.doi.org/10.1016/S0093-7754(02)70136-X] [PMID: 12138407]

Bokhman, J.V. Two pathogenetic types of endometrial carcinoma. Gynecol. Oncol., 1983, 15(1), 10-17.
[http://dx.doi.org/10.1016/0090-8258(83)90111-7] [PMID: 6822361]

Zhu, Y.; Shen, J.; Gao, L.; Feng, Y. Estrogen promotes fat mass and obesity-associated protein nuclear localization and enhances endometrial cancer cell proliferation via the mTOR signaling pathway. Oncol. Rep., 2016, 35(4), 2391-2397.
[http://dx.doi.org/10.3892/or.2016.4613] [PMID: 26884084]

Lurie, G.; Gaudet, M.M.; Spurdle, A.B.; Carney, M.E.; Wilkens, L.R.; Yang, H.P.; Weiss, N.S.; Webb, P.M.; Thompson, P.J.; Terada, K.; Setiawan, V.W.; Rebbeck, T.R.; Prescott, J.; Orlow, I.; O’Mara, T.; Olson, S.H.; Narod, S.A.; Matsuno, R.K.; Lissowska, J.; Liang, X.; Levine, D.A.; Le Marchand, L.; Kolonel, L.N.; Henderson, B.E.; Garcia-Closas, M.; Doherty, J.A.; De Vivo, I.; Chen, C.; Brinton, L.A.; Akbari, M.R.; Goodman, M.T. The obesity-associated polymorphisms FTO rs9939609 and MC4R rs17782313 and endometrial cancer risk in non-Hispanic white women. PLoS One, 2011, 6(2)e16756
[http://dx.doi.org/10.1371/journal.pone.0016756] [PMID: 21347432]

Zhang, Z.; Zhou, D.; Lai, Y.; Liu, Y.; Tao, X.; Wang, Q.; Zhao, G.; Gu, H.; Liao, H.; Zhu, Y.; Xi, X.; Feng, Y. Estrogen induces endometrial cancer cell proliferation and invasion by regulating the fat mass and obesity-associated gene via PI3K/AKT and MAPK signaling pathways. Cancer Lett., 2012, 319(1), 89-97.
[http://dx.doi.org/10.1016/j.canlet.2011.12.033] [PMID: 22222214]

Liu, J.; Eckert, M.A.; Harada, B.T.; Liu, S.M.; Lu, Z.; Yu, K.; Tienda, S.M.; Chryplewicz, A.; Zhu, A.C.; Yang, Y.; Huang, J.T.; Chen, S.M.; Xu, Z.G.; Leng, X.H.; Yu, X.C.; Cao, J.; Zhang, Z.; Liu, J.; Lengyel, E.; He, C. m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer. Nat. Cell Biol., 2018, 20(9), 1074-1083.
[http://dx.doi.org/10.1038/s41556-018-0174-4] [PMID: 30154548]

Delahanty, R.J.; Beeghly-Fadiel, A.; Xiang, Y.B.; Long, J.; Cai, Q.; Wen, W.; Xu, W.H.; Cai, H.; He, J.; Gao, Y.T.; Zheng, W.; Shu, X.O. Association of obesity-related genetic variants with endometrial cancer risk: a report from the Shanghai Endometrial Cancer Genetics Study. Am. J. Epidemiol., 2011, 174(10), 1115-1126.
[http://dx.doi.org/10.1093/aje/kwr233] [PMID: 21976109]

Chen, B.; Ye, F.; Yu, L.; Jia, G.; Huang, X.; Zhang, X.; Peng, S.; Chen, K.; Wang, M.; Gong, S.; Zhang, R.; Yin, J.; Li, H.; Yang, Y.; Liu, H.; Zhang, J.; Zhang, H.; Zhang, A.; Jiang, H.; Luo, C.; Yang, C.G. Development of cell-active N6-methyladenosine RNA demethylase FTO inhibitor. J. Am. Chem. Soc., 2012, 134(43), 17963-17971.
[http://dx.doi.org/10.1021/ja3064149] [PMID: 23045983]

Aik, W.; Demetriades, M.; Hamdan, M.K.; Bagg, E.A.; Yeoh, K.K.; Lejeune, C.; Zhang, Z.; McDonough, M.A.; Schofield, C.J. Structural basis for inhibition of the fat mass and obesity associated protein (FTO). J. Med. Chem., 2013, 56(9), 3680-3688.
[http://dx.doi.org/10.1021/jm400193d] [PMID: 23547775]

Su, R.; Dong, L.; Li, C.; Nachtergaele, S.; Wunderlich, M.; Qing, Y.; Deng, X.; Wang, Y.; Weng, X.; Hu, C.; Yu, M.; Skibbe, J.; Dai, Q.; Zou, D.; Wu, T.; Yu, K.; Weng, H.; Huang, H.; Ferchen, K.; Qin, X.; Zhang, B.; Qi, J.; Sasaki, A.T.; Plas, D.R.; Bradner, J.E.; Wei, M.; Marcucci, G.; Jiang, X.; Mulloy, J.C.; Jin, J.; He, C.; Chen, J. R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling. Cell, 2018, 172(1-2), 90-105.e23.
[http://dx.doi.org/10.1016/j.cell.2017.11.031] [PMID: 29249359]

Fu, X.; Chin, R.M.; Vergnes, L.; Hwang, H.; Deng, G.; Xing, Y.; Pai, M.Y.; Li, S.; Ta, L.; Fazlollahi, F.; Chen, C.; Prins, R.M.; Teitell, M.A.; Nathanson, D.A.; Lai, A.; Faull, K.F.; Jiang, M.; Clarke, S.G.; Cloughesy, T.F.; Graeber, T.G.; Braas, D.; Christofk, H.R.; Jung, M.E.; Reue, K.; Huang, J. 2-Hydroxyglutarate inhibits ATP synthase and m TOR signaling. Cell Metab., 2015, 22(3), 508-515.
[http://dx.doi.org/10.1016/j.cmet.2015.06.009] [PMID: 26190651]

Huang, Y.; Yan, J.; Li, Q.; Li, J.; Gong, S.; Zhou, H.; Gan, J.; Jiang, H.; Jia, G.F.; Luo, C.; Yang, C.G. Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5. Nucleic Acids Res., 2015, 43(1), 373-384.
[http://dx.doi.org/10.1093/nar/gku1276] [PMID: 25452335]

Huang, Y.; Su, R.; Sheng, Y.; Dong, L.; Dong, Z.; Xu, H.; Ni, T.; Zhang, Z.S.; Zhang, T.; Li, C.; Han, L.; Zhu, Z.; Lian, F.; Wei, J.; Deng, Q.; Wang, Y.; Wunderlich, M.; Gao, Z.; Pan, G.; Zhong, D.; Zhou, H.; Zhang, N.; Gan, J.; Jiang, H.; Mulloy, J.C.; Qian, Z.; Chen, J.; Yang, C.G. Small-molecule targeting of oncogenic FTO demethylase in acute myeloid leukemia. Cancer Cell, 2019, 35(4), 677-691.e10.
[http://dx.doi.org/10.1016/j.ccell.2019.03.006] [PMID: 30991027]

Qiao, Y.; Zhou, B.; Zhang, M.; Liu, W.; Han, Z.; Song, C.; Yu, W.; Yang, Q.; Wang, R.; Wang, S.; Shi, S.; Zhao, R.; Chai, J.; Chang, J. A Novel Inhibitor of the Obesity-Related Protein FTO. Biochemistry, 2016, 55(10), 1516-1522.
[http://dx.doi.org/10.1021/acs.biochem.6b00023] [PMID: 26915401]