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Current Women`s Health Reviews

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ISSN (Print): 1573-4048
ISSN (Online): 1875-6581

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Case Report

Vaginitis Due to Pichia fermentans in a Patient Affected by Endometrial Cancer: A Novel Case Report

Author(s): Zarifeh Adampour, Malihe Hasanzadeh, Hossein Zarrinfar*, Maryam Nakhaei and Monika Novak Babi

Volume 18, Issue 4, 2022

Article ID: e031121194726 Pages: 4

DOI: 10.2174/1573404817666210712214458

Price: $65

Abstract

Introduction: Endometrial cancer is one of the most common malignancies of the female genital tract, which can be serious or life-threatening. Microbial infections can be one of the underlying causes of this type of cancer.

Case Presentation: The present study describes the isolation of Pichia fermentans (Candida firmentaria var. firmentaria) from the vaginal secretions of a 61-year-old woman affected by endometrial cancer. She reported abdominal pain and vaginal discharge for 3 months, and had a history of diabetes, hypertension, Deep Vein Thrombosis (DVT), and Acute Myeloid Leukemia (AML). The isolated yeast was identified based on nuclear ribosomal internal transcribed spacer (ITS1-ITS2 rDNA) sequence analysis. The in vitro antifungal susceptibility testing showed a higher effect for ketoconazole against P. fermentans than fluconazole, itraconazole and voriconazole.

Conclusion: Correct differentiation between P. fermentans and other yeast should be considered. In vitro antifungal susceptibility testing is recommended for rare yeast, and will help the physicians in providing the best treatment.

Keywords: Vaginitis, Pichia fermentans, uterine cancer, Candida, woman, PCR.

Graphical Abstract

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