摘要
三阴性乳腺癌(TNBC)是乳腺癌的一种高度耐药、致死性和转移性亚型,以雌激素受体(ER)、孕激素受体(PR)和人表皮生长因子受体2(HER2)缺乏为特征。 )。在女性中,TNBC 表现出更高的攻击性行为,患者预后较差,育龄期复发率更高。 TNBC 的定义是存在上皮间质转化 (EMT),这在癌症进展中发挥了重要作用。在表观遗传水平上,TNBC 以表观遗传特征为特征,例如 DNA 甲基化、组蛋白重塑和大量 miRNA、MiR-193、LncRNA、HIF-2α、eEF2K、LIN9/NEK2、IMP3、LISCH7/TGF-β1、 GD3s、KLK12、介导调节。这些修饰要么被沉默,要么激活在 TNBC 中普遍存在的必要基因。该综述基于 TNBC 中表观遗传介导的机制变化。此外,百里醌(TQ)、瑞戈非尼、防己黄芪汤、柴胡皂甙A、槐耳等是文献中广泛报道的强效抗肿瘤天然化合物。此外,该综述强调了这些天然化合物在 TNBC 中的作用及其可能的表观遗传靶点,可用作治疗 TNBC 的潜在治疗策略。
关键词: TNBC、基因、DNA 甲基化、天然化合物、乳腺癌、雌激素受体
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