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Review Article

深入了解草药单胺氧化酶抑制剂在神经系统疾病中的治疗潜力与机制

卷 23, 期 3, 2022

发表于: 07 July, 2021

页: [286 - 310] 页: 25

弟呕挨: 10.2174/1389450122666210707120256

价格: $65

摘要

单胺氧化酶 (MAO) 是一种催化单胺和其他蛋白质脱氨基的酶。 MAO 的过度活化导致活性氧的大量产生，从而导致多种神经系统疾病，如阿尔茨海默病、帕金森病、肌萎缩侧索硬化症、亨廷顿病和抑郁症样疾病。虽然合成 MAO 抑制剂在临床上可用，但它们与诸如肝毒性、奶酪反应、高血压危象等副作用有关，因此需要研究具有安全特性的天然来源的替代 MAO 抑制剂。草药对许多疾病的预防有显着影响；此外，它们的副作用较少，可作为药物开发的先驱。本综述讨论了草药 MAO 抑制剂的潜力及其相关的作用机制，旨在促进未来对草药 MAO 抑制剂作为神经系统疾病潜在治疗方法的研究。

关键词: 黄素酶、单胺氧化酶抑制剂、细胞凋亡、神经系统疾病、阿尔茨海默病、帕金森病、氧化应激

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