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Current Nutrition & Food Science

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ISSN (Print): 1573-4013
ISSN (Online): 2212-3881

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Clinical Trial

Antihyperglycemic Effect of Fenugreek and Ginger in Patients with Type 2 Diabetes: A Double-Blind, Placebo-controlled Study

Author(s): Mohamed A. Elsaadany*, Hussah M. AlTwejry, Rwabi A. Zabran, Sara A. AlShuraim, Wala'a A. AlShaia, Omar I. Abuzaid and Waleed I. AlBaker

Volume 18, Issue 2, 2022

Published on: 06 January, 2022

Page: [231 - 237] Pages: 7

DOI: 10.2174/1573401317666210706121806

Price: $65

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Abstract

Background: Type 2 diabetes mellitus (T2DM) is a worldwide chronic, complex, and progressive disease that usually requires combination therapy for improved glycemic control. Although conventional medicine showed more potency than herbal medicine, a combination of both may result in better therapeutic outcomes with fewer side effects.

Objective: This study was conducted to investigate the antihyperglycemic potential of fenugreek seeds (Trigonellafoenum-graecum L.) and ginger root (Zingiber officinalis) in patients with T2DM along with their usual antidiabetic medications.

Methods: A double-blind, placebo-controlled study was conducted using 33 cases, who were randomly divided into three groups. The first group received oral placebo capsules (1 g 3 times a day) and served as a control group, while the other two groups each received capsules of either fenugreek or ginger powder of the same dosage (1 g 3 times a day). The study was conducted for 8 weeks and treatment effects in patients were assessed through the measurements of serum’s fasting blood sugar (FBS), HbA1c, lipid profile, as well as kidney and liver functions.

Results and Discussion: After 8 weeks of intervention, fenugreek and ginger induced a significant reduction in FBS by 19.1 ± 3.8% and 16.0 ± 8.0% compared to their baselines, respectively (p ≤ 0.05). Moreover, fenugreek significantly reduced HbA1c by 15.9 ± 4.9% compared to the baseline, while ginger did not. Creatinine and triglyceride levels were also reduced significantly (p ≤ 0.05) compared to their baselines in both fenugreek and ginger groups. However, all the other parameters did not significantly change.

Conclusion: This study provides evidence that using fenugreek and ginger may enhance glycemic control in T2DM patients. Additionally, they might improve kidney function and lipids profile.

Clinical Trial Registeration: The clinical trial has been registered with the number (2015-03‐229) at King Fahd University Hospital, Dammam, Saudi Arabia.

Keywords: Diabetes, fenugreek, ginger, double-blind, HbA1c, lipid profile, creatinine, trial registration.

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[1]
Roifman I, Ghugre N, Zia MI, et al. Diabetes is an independent predictor of right ventricular dysfunction post ST-elevation myocardial infarction. Cardiovasc Diabetol 2016; 15: 34.
[http://dx.doi.org/10.1186/s12933-016-0352-2] [PMID: 26892325]
[2]
Alwin Robert A, Al Dawish MA. Microvascular complications among patients with diabetes: An emerging health problem in Saudi Arabia. Diab Vasc Dis Res 2019; 16(3): 227-35.
[http://dx.doi.org/10.1177/1479164118820714] [PMID: 30599757]
[3]
Fujiwara Y, Eguchi S, Murayama H, et al. Relationship between diet/exercise and pharmacotherapy to enhance the GLP-1 levels in type 2 diabetes. Endocrinol Diabetes Metab 2019; 2(3): e00068.
[http://dx.doi.org/10.1002/edm2.68] [PMID: 31294084]
[4]
Hooda A, Mehta A, Hannallah F. Metformin-associated lactic acidosis precipitated by liraglutide use: Adverse effects of aggressive antihyperglycaemic therapy. BMJ Case Rep 2018; 11(1): e227102.
[http://dx.doi.org/10.1136/bcr-2018-227102] [PMID: 30567126]
[5]
Alves Ferreira M, Oliveira Gomes AP, Guimarães de Moraes AP, et al. Green tea extract outperforms metformin in lipid profile and glycaemic control in overweight women: A double-blind, placebo-controlled, randomized trial. Clin Nutr ESPEN 2017; 22: 1-6.
[http://dx.doi.org/10.1016/j.clnesp.2017.08.008] [PMID: 29415825]
[6]
Pająk P, Socha R, Broniek J, Królikowska K, Fortuna T. Antioxidant properties, phenolic and mineral composition of germinated chia, golden flax, evening primrose, phacelia and fenugreek. Food Chem 2019; 275: 69-76.
[http://dx.doi.org/10.1016/j.foodchem.2018.09.081] [PMID: 30724250]
[7]
Pundarikakshudu K, Shah DH, Panchal AH, Bhavsar GC. Anti-inflammatory activity of fenugreek (Trigonella foenum-graecum Linn) seed petroleum ether extract. Indian J Pharmacol 2016; 48(4): 441-4.
[http://dx.doi.org/10.4103/0253-7613.186195] [PMID: 27756958]
[8]
Shabbeer S, Sobolewski M, Anchoori RK, et al. Fenugreek: A naturally occurring edible spice as an anticancer agent. Cancer Biol Ther 2009; 8(3): 272-8.
[http://dx.doi.org/10.4161/cbt.8.3.7443] [PMID: 19197146]
[9]
Shivashankara AR, Azmidah A, Haniadka R, Rai MP, Arora R, Baliga MS. Dietary agents in the prevention of alcohol-induced hepatotoxicty: Preclinical observations. Food Funct 2012; 3(2): 101-9.
[http://dx.doi.org/10.1039/C1FO10170F] [PMID: 22119904]
[10]
Nagulapalli Venkata KC, Swaroop A, Bagchi D, Bishayee A. A small plant with big benefits: Fenugreek (Trigonella foenum-graecum Linn.) for disease prevention and health promotion. Mol Nutr Food Res 2017; 61(6)
[http://dx.doi.org/10.1002/mnfr.201600950] [PMID: 28266134]
[11]
Huang FY, Deng T, Meng LX, Ma XL. Dietary ginger as a traditional therapy for blood sugar control in patients with type 2 diabetes mellitus: A systematic review and meta-analysis. Medicine (Baltimore) 2019; 98(13): e15054.
[http://dx.doi.org/10.1097/MD.0000000000015054] [PMID: 30921234]
[12]
Jiang TA. Health benefits of culinary herbs and spices. J AOAC Int 2019; 102(2): 395-411.
[http://dx.doi.org/10.5740/jaoacint.18-0418] [PMID: 30651162]
[13]
Hasani-Ranjbar S, Nayebi N, Moradi L, Mehri A, Larijani B, Abdollahi M. The efficacy and safety of herbal medicines used in the treatment of hyperlipidemia; A systematic review. Curr Pharm Des 2010; 16(26): 2935-47.
[http://dx.doi.org/10.2174/138161210793176464] [PMID: 20858178]
[14]
Hasani H, Arab A, Hadi A, Pourmasoumi M, Ghavami A, Miraghajani M. Does ginger supplementation lower blood pressure? A systematic review and meta-analysis of clinical trials. Phytother Res 2019; 33(6): 1639-47.
[http://dx.doi.org/10.1002/ptr.6362] [PMID: 30972845]
[15]
Chen D, Zhao J, Cong W. Chinese herbal medicines facilitate the control of chemotherapy-induced side effects in colorectal cancer: Progress and perspective. Front Pharmacol 2018; 9: 1442.
[http://dx.doi.org/10.3389/fphar.2018.01442] [PMID: 30581388]
[16]
Ebrahimzadeh Attari V, Somi MH, Asghari Jafarabadi M, Ostadrahimi A, Moaddab SY, Lotfi N. The gastro-protective effect of ginger (Zingiber officinale Roscoe) in Helicobacter pylori positive functional dyspepsia. Adv Pharm Bull 2019; 9(2): 321-4.
[http://dx.doi.org/10.15171/apb.2019.038] [PMID: 31380260]
[17]
Nikkhah-Bodaghi M, Maleki I, Agah S, Hekmatdoost A. Zingiber officinale and oxidative stress in patients with ulcerative colitis: A randomized, placebo-controlled, clinical trial. Complement Ther Med 2019; 43: 1-6.
[http://dx.doi.org/10.1016/j.ctim.2018.12.021] [PMID: 30935515]
[18]
Rahimlou M, Yari Z, Hekmatdoost A, Alavian SM, Keshavarz SA. Ginger supplementation in nonalcoholic fatty liver disease: A randomized, double-blind, placebo-controlled pilot study. Hepat Mon 2016; 16(1): e34897.
[http://dx.doi.org/10.5812/hepatmon.34897] [PMID: 27110262]
[19]
Akash MS, Rehman K, Tariq M, Chen S. Zingiber officinale and type 2 diabetes mellitus: Evidence from experimental studies. Crit Rev Eukaryot Gene Expr 2015; 25(2): 91-112.
[http://dx.doi.org/10.1615/CritRevEukaryotGeneExpr.2015013358] [PMID: 26080605]
[20]
Jin Y, Shi Y, Zou Y, Miao C, Sun B, Li C. Fenugreek prevents the development of stz-induced diabetic nephropathy in a rat model of diabetes. Evid Based Complement Alternat Med 2014; 2014259368
[http://dx.doi.org/10.1155/2014/259368] [PMID: 25057273]
[21]
Jiang W, Si L, Li P, et al. Serum metabonomics study on antidiabetic effects of fenugreek flavonoids in streptozotocin-induced rats. J Chromatogr B Analyt Technol Biomed Life Sci 2018; 1092: 466-72.
[http://dx.doi.org/10.1016/j.jchromb.2018.06.041] [PMID: 30008302]
[22]
Hadi A, Arab A, Hajianfar H, et al. The effect of fenugreek seed supplementation on serum irisin levels, blood pressure, and liver and kidney function in patients with type 2 diabetes mellitus: A parallel randomized clinical trial. Complement Ther Med 2020; 49102315
[http://dx.doi.org/10.1016/j.ctim.2020.102315] [PMID: 32147060]
[23]
Ranade M, Mudgalkar N. A simple dietary addition of fenugreek seed leads to the reduction in blood glucose levels: A parallel group, randomized single-blind trial. Ayu 2017; 38(1-2): 24-7.
[http://dx.doi.org/10.4103/ayu.AYU_209_15] [PMID: 29861588]
[24]
Imani H, Tabibi H, Najafi I, Atabak S, Hedayati M, Rahmani L. Effects of ginger on serum glucose, advanced glycation end products, and inflammation in peritoneal dialysis patients. Nutrition 2015; 31(5): 703-7.
[http://dx.doi.org/10.1016/j.nut.2014.11.020] [PMID: 25837216]
[25]
Makhdoomi Arzati M, Mohammadzadeh Honarvar N, Saedisomeolia A, et al. The effects of ginger on fasting blood sugar, hemoglobin a1c, and lipid profiles in patients with type 2 diabetes. Int J Endocrinol Metab 2017; 15(4): e57927.
[http://dx.doi.org/10.5812/ijem.57927] [PMID: 29344037]
[26]
Carvalho GCN, Lira-Neto JCG, Araújo MFM, Freitas RWJF, Zanetti ML, Damasceno MMC. Effectiveness of ginger in reducing metabolic levels in people with diabetes: A randomized clinical trial. Rev Lat Am Enfermagem 2020; 28: e3369.
[http://dx.doi.org/10.1590/1518-8345.3870.3369] [PMID: 33053078]
[27]
Geberemeskel GA, Debebe YG, Nguse NA. Antidiabetic effect of fenugreek seed powder solution (Trigonella foenum-graecum L.) on hyperlipidemia in diabetic patients. J Diabetes Res 2019; 20198507453
[http://dx.doi.org/10.1155/2019/8507453] [PMID: 31583253]
[28]
Najdi RA, Hagras MM, Kamel FO, Magadmi RM. A randomized controlled clinical trial evaluating the effect of Trigonella foenum-graecum (fenugreek) versus glibenclamide in patients with diabetes. Afr Health Sci 2019; 19(1): 1594-601.
[http://dx.doi.org/10.4314/ahs.v19i1.34] [PMID: 31148988]
[29]
Mahluji S, Attari VE, Mobasseri M, Payahoo L, Ostadrahimi A, Golzari SE. Effects of ginger (Zingiber officinale) on plasma glucose level, HbA1c and insulin sensitivity in type 2 diabetic patients. Int J Food Sci Nutr 2013; 64(6): 682-6.
[http://dx.doi.org/10.3109/09637486.2013.775223] [PMID: 23496212]
[30]
Pourmasoumi M, Hadi A, Rafie N, Najafgholizadeh A, Mohammadi H, Rouhani MH. The effect of ginger supplementation on lipid profile: A systematic review and meta-analysis of clinical trials. Phytomedicine 2018; 43: 28-36.
[http://dx.doi.org/10.1016/j.phymed.2018.03.043] [PMID: 29747751]
[31]
Heshmat-Ghahdarijani K, Mashayekhiasl N, Amerizadeh A, Teimouri Jervekani Z, Sadeghi M. Effect of fenugreek consumption on serum lipid profile: A systematic review and meta-analysis. Phytother Res 2020; 34(9): 2230-45.
[http://dx.doi.org/10.1002/ptr.6690] [PMID: 32385866]
[32]
Yella SST, Kumar RN, Ayyanna C, Varghese AM, Amaravathi P, Vangoori Y. The combined effect of Trigonella foenum seeds and Coriandrum sativum leaf extracts in alloxan-induced diabetes mellitus Wistar albino rats. Bioinformation 2019; 15(10): 716-22.
[http://dx.doi.org/10.6026/97320630015716] [PMID: 31831953]
[33]
Al Hroob AM, Abukhalil MH, Alghonmeen RD, Mahmoud AM. Ginger alleviates hyperglycemia-induced oxidative stress, inflammation and apoptosis and protects rats against diabetic nephropathy. Biomed Pharmacother 2018; 106: 381-9.
[http://dx.doi.org/10.1016/j.biopha.2018.06.148] [PMID: 29966984]
[34]
Shirpoor A, Rezaei F, Fard AA, Afshari AT, Gharalari FH, Rasmi Y. Ginger extract protects rat’s kidneys against oxidative damage after chronic ethanol administration. Biomed Pharmacother 2016; 84: 698-704.
[http://dx.doi.org/10.1016/j.biopha.2016.09.097] [PMID: 27710894]
[35]
Gong J, Fang K, Dong H, Wang D, Hu M, Lu F. Effect of fenugreek on hyperglycaemia and hyperlipidemia in diabetes and prediabetes: A meta-analysis. J Ethnopharmacol 2016; 194: 260-8.
[http://dx.doi.org/10.1016/j.jep.2016.08.003] [PMID: 27496582]
[36]
Fuller S, Stephens JM. Diosgenin, 4-hydroxyisoleucine, and fiber from fenugreek: Mechanisms of actions and potential effects on metabolic syndrome. Adv Nutr 2015; 6(2): 189-97.
[http://dx.doi.org/10.3945/an.114.007807] [PMID: 25770257]
[37]
Singh P, Bajpai V, Gond V, Kumar A, Tadigoppula N, Kumar B. Determination of bioactive compounds of fenugreek (Trigonella foenum-graecum) seeds using LC-MS techniques. Methods Mol Biol 2020; 2107: 377-93.
[http://dx.doi.org/10.1007/978-1-0716-0235-5_21] [PMID: 31893460]
[38]
Li Y, Tran VH, Duke CC, Roufogalis BD. Preventive and protective properties of Zingiber officinale (ginger) in diabetes mellitus, diabetic complications, and associated lipid and other metabolic disorders: A brief review. Evid Based Complement Alternat Med 2012; 2012516870
[http://dx.doi.org/10.1155/2012/516870] [PMID: 23243452]

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