Augmentation Therapy with Alpha-1 Antitrypsin: Present and Future
of Production, Formulation, and Delivery

Annalisa       Bianchera; Esraa       Alomari; Stefano       Bruno
doi:10.2174/0929867328666210525161942
Abstract

Alpha 1-antitrypsin is one of the first protein therapeutics introduced on the market more than 30 years ago, and to date, it is indicated only for the treatment of the severe forms of a genetic condition known as alpha-1 antitrypsin deficiency. The only approved preparations are derived from plasma, posing potential problems associated with its limited supply and high processing costs. Moreover, augmentation therapy with alpha-1 antitrypsin is still limited to intravenous infusions, a cumbersome regimen for patients. Here, we review the recent literature on its possible future developments, focusing on i) the recombinant alternatives to the plasma-derived protein, ii) novel formulations, and iii) novel administration routes. Regulatory issues and the still unclear noncanonical functions of alpha-1 antitrypsin, possibly associated with the glycosylation pattern found only in the plasma-derived protein, have hindered the introduction of new products. However, potentially new therapeutic indications other than the treatment of alpha-1 antitrypsin deficiency might open the way to new sources and new formulations.
Keywords: Alpha 1-antitrypsin, alpha 1-proteinase inhibitor, neutrophil elastase, augmentation therapy, protein therapeutics formulation, pulmonary drug delivery
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DOI https://dx.doi.org/10.2174/0929867328666210525161942	Print ISSN 0929-8673
Publisher Name Bentham Science Publisher	Online ISSN 1875-533X
Current Medicinal Chemistry

Augmentation Therapy with Alpha-1 Antitrypsin: Present and Future of Production, Formulation, and Delivery

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