摘要
背景:脂多糖 (LPS) 是一种革兰氏阴性细菌细胞壁成分,可在人体内引起强烈的炎症反应。自然地,炎症是宿主对感染的免疫反应的一部分。尽管如此,过度反应会导致一系列病理生理后果,统称为 LPS 毒性或感染性休克。 目的:本综述将探讨主要关注姜黄素对 LPS 介导的炎症反应的治疗作用的细胞和实验研究。 方法:对所有相关研究进行文献回顾。 结论:据报道,姜黄素通过干扰 LPS 诱导的炎症通路发挥抗炎特性,包括与 LPS 细胞表面受体的结合、NF-kB 激活通路和炎症小体激活。关于姜黄素在减少 LPS 毒性病理生理后果方面的作用的进一步临床研究将证实该分子在未来治疗方法中的用途。
关键词: 姜黄素、脂多糖、姜黄、感染性休克、炎症、细胞因子、白细胞介素。
Current Medicinal Chemistry
Title:Protective Effects of Curcumin against Lipopolysaccharide-Induced Toxicity
Volume: 28 Issue: 33
关键词: 姜黄素、脂多糖、姜黄、感染性休克、炎症、细胞因子、白细胞介素。
摘要:
Background: Lipopolysaccharide (LPS), a Gram-negative bacterial cell wall component, evokes intensive inflammatory responses in the human body. Naturally, inflammation is a part of the host immune response to an infection; nonetheless, an exaggerated response can lead to a series of pathophysiological consequences, collectively known as LPS toxicity or septic shock.
Objective: This review will explore the cellular and experimental investigations that mainly focus on Curcumin's therapeutic effects on the LPS-mediated inflammatory responses.
Method: A literature review of all relevant studies was performed.
Conclusion: Curcumin has been reported to exert anti-inflammatory properties by interfering with LPS-induced inflammatory pathways, including binding to cell surface receptors of LPS, NF-kB activation pathway, and inflammasome activation. Further clinical studies on the effect of Curcumin in reducing the pathophysiological consequences of LPS toxicity would substantiate the use of this molecule for future therapeutic approaches.
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Cite this article as:
Protective Effects of Curcumin against Lipopolysaccharide-Induced Toxicity, Current Medicinal Chemistry 2021; 28 (33) . https://dx.doi.org/10.2174/0929867328666210525124707
DOI https://dx.doi.org/10.2174/0929867328666210525124707 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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