Regulating Inflammation Associated Ferroptosis - A Treatment Strategy for Parkinson Disease

Title:Regulating Inflammation Associated Ferroptosis - A Treatment Strategy for Parkinson Disease

Volume: 28 Issue: 33

Author(s): Marthandam Asokan Shibu, Mahalakshmi Bharath and Bharath Kumar Velmurugan*

Affiliation:

• Department of Medical Laboratory Science and Biotechnology, Asia University, Taichung,Taiwan

Keywords: Ferroptosis, Parkinson's disease, iron accumulation, inflammation, neurodegeneration, drugs.

Abstract: Ferroptosis plays a critical regulatory role as a new kind of cell death, initiating and developing an array of disorders like neurological diseases, acute injury of kidney, tumors, and ischemia, etc. Although selective deposition of iron is one of the pathogenic reasons for PD, it’s underlying mechanism is still unknown. In this review, the role of neuroinflammation in Parkinson’s disease (PD) leading to neurodegeneration has been discussed in detail. The accumulation of brain iron has been found in many chronic neurological disorders, including PD. We have also discussed the unique features of ferroptosis , and it links in aggravating the pathology of PD. Further, the concept of targeting ferroptosis for PD pathology and inducers and inhibitors, pharmacological drugs and clinical trials for PD candidates in phase IV stage in completed status are detailed in the respective sections.

Cite this article as:

Shibu Asokan Marthandam , Bharath Mahalakshmi and Velmurugan Kumar Bharath*, Regulating Inflammation Associated Ferroptosis - A Treatment Strategy for Parkinson Disease, Current Medicinal Chemistry 2021; 28 (33) . https://dx.doi.org/10.2174/0929867328666210419125032