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Mini-Review Article

登革热病毒进入抑制剂的挑战和前景

卷 29, 期 4, 2022

发表于: 09 July, 2021

页: [719 - 740] 页: 22

弟呕挨: 10.2174/0929867328666210521213118

价格: $65

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摘要

登革热病毒（DENV）疾病已成为公共卫生领域的主要挑战之一。目前，没有针对这种感染的抗病毒治疗。由于人类传播是通过伊蚊属的蚊子传播的，因此大多数努力都集中在控制这种媒介上。然而，这些控制策略并未完全成功，这反映在每年 DENV 感染数量不断增加，成为全球 100 多个国家的地方病。因此，迫切需要开发一种安全的抗病毒药物。从这个意义上说，合理的设计方法已应用于开发抑制病毒复制周期中一个或多个步骤的抗病毒化合物。病毒进入宿主细胞是感染的早期和特定阶段。靶向病毒成分或细胞蛋白靶点是治疗干预病毒感染的一种负担得起且有效的策略。这篇综述对迄今为止作为 DENV 进入直接作用的抗病毒剂进行测试的有机小分子、肽和无机部分进行了广泛的概述。将讨论基于计算机辅助药物设计 (CADD) 策略和传统药物化学方法设计和评估 DENV 病毒进入抑制剂的最新进展。此外，还将详细讨论药物的物理化学性质，例如溶解度、亲脂性、稳定性以及临床前和临床研究的当前结果。

关键词: 登革热病毒、进入抑制剂、计算机辅助药物设计、包膜蛋白、小分子、肽、无机化合物

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