摘要
金属酶和金属蛋白的生物合成所需的一些过渡金属,如锰、铁、钴、镍、铜和锌,是病原微生物生长发育所必需的微量营养素。在宿主生物体采取的防御措施中,所谓的“营养免疫”包括减少微量营养素的可用性,从而“饿死”病原体。在金属的情况下,微生物可以通过不同的方式对抗营养免疫,即通过直接吸收金属离子或捕获细胞外金属蛋白,或者通过合成特定的金属团,允许以螯合物的形式输入金属。最著名和研究最多的金属载体是那些针对铁(铁载体)的金属载体,但微生物也表达类似的螯合剂以捕获其他金属,例如锌。还可以通过专门的锌结合蛋白来实现有效的锌补充。对胞质外锌螯合剂的性质、结构和作用机制的深入了解可以成为寻找针对抗生素和/或抗真菌耐药性的新治疗策略的有力工具。本综述旨在收集有关由对人体致病的细菌或真菌微生物表达的锌载体(负责锌获取的小分子和蛋白质)的知识。
关键词: 锌基、金属结合蛋白、锌、营养免疫、细菌、真菌、抗菌剂。
Current Medicinal Chemistry
Title:How Zinc-Binding Systems, Expressed by Human Pathogens, Acquire Zinc from the Colonized Host Environment: A Critical Review on Zincophores
Volume: 28 Issue: 35
关键词: 锌基、金属结合蛋白、锌、营养免疫、细菌、真菌、抗菌剂。
摘要: Some transition metals, like manganese, iron, cobalt, nickel, copper and zinc, required for the biosynthesis of metalloenzymes and metalloproteins, are essential micronutrients for the growth and development of pathogenic microorganisms. Among the defenses put in place by the host organism, the so-called “nutritional immunity” consists of reducing the availability of micronutrients and thus “starving” the pathogen. In the case of metals, microorganisms can fight the nutritional immunity in different ways, i.e. by directly recruiting the metal ion or capturing an extracellular metalloprotein or also through the synthesis of specific metallophores which allow importing the metal in the form of a chelate complex. The best known and most studied metallophores are those directed to iron (siderophores), but analogous chelators are also expressed by microorganisms to capture other metals, such as zinc. An efficient zinc recruitment can also be achieved by means of specialized zinc-binding proteins. A deep knowledge of the properties, structure and action mechanisms of extracytoplasmic zinc chelators can be a powerful tool to find out new therapeutic strategies against the antibiotic and/or antifungal resistance. This review aims to collect the knowledge concerning zincophores (small molecules and proteins in charge of zinc acquisition) expressed by bacterial or fungal microorganisms that are pathogenic for the human body.
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Cite this article as:
How Zinc-Binding Systems, Expressed by Human Pathogens, Acquire Zinc from the Colonized Host Environment: A Critical Review on Zincophores, Current Medicinal Chemistry 2021; 28 (35) . https://dx.doi.org/10.2174/1389200222666210514012945
DOI https://dx.doi.org/10.2174/1389200222666210514012945 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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