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ISSN (Print): 1574-8928
ISSN (Online): 2212-3970

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Review Article

A Link Between Chemical Structure and Biological Activity in Triterpenoids

Author(s): Li Zang, Hao Xu, Chao Huang, Cunqin Wang*, Rongbin Wang*, Ying Chen, Lei Wang and Hongting Wang*

Volume 17, Issue 2, 2022

Published on: 15 February, 2022

Page: [145 - 161] Pages: 17

DOI: 10.2174/1574892816666210512031635

Price: $65

Abstract

Background: Plants that are rich in triterpenoid compounds possess various biological activities and are reported in many scientific works. Triterpenoids, because of their broad sources, wide variety, high medicinal value, and anti-tumor properties, have drawn great attention from scientists. However, the lack of approach to understand the link between their chemical structures and biological activities has limited the fundamental comprehension of these compounds in cancer therapy.

Objective: The aim of the study is to summarize the list of plants with triterpenoids and their derivatives that are a source of potential novel therapeutic anti-cancer agents by interpreting the network of anti-cancer activity and the structures of triterpenoids and their derivatives.

Methods: This work focuses on analyzing relevant patents and references that detail the structure of triterpenoids and their derivatives for the treatment of tumors.

Results: Pentacyclic triterpenoid plays a more important role in improving the autophagic signaling pathways of cancer cells compared to tetracyclic triterpenoid.

Conclusion: The heterogenous skeleton structure of triterpenoids impairs programmed cell death signaling pathways in various cancers.

Keywords: Triterpenoids, classification, chemical structure, programmed cell death, autoghagy, apoptosis.

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