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Review Article

具有 I 类融合蛋白的高致病性包膜病毒的六螺旋束核心的病毒进入抑制剂

卷 29, 期 4, 2022

发表于: 11 January, 2022

页: [700 - 718] 页: 19

弟呕挨: 10.2174/0929867328666210511015808

价格: $65

摘要

Ⅰ型包膜病毒通过表面糖蛋白与细胞受体结合启动感染或经历受体介导的内吞作用，在内吞区室的酸性环境中启动膜融合，将遗传物质释放到细胞内。在膜融合过程中，包膜蛋白暴露融合肽，然后插入细胞膜或内体膜。随后发生了进一步的构象变化，其中 1 型包膜蛋白形成典型的六螺旋束结构，缩短了病毒和细胞膜之间的距离，从而可以发生融合。针对病毒包膜蛋白或宿主因子的进入抑制剂是有效的抗病毒剂，并已被广泛研究。有些已在临床上使用，例如用于人类免疫缺陷病毒 1 (HIV-1) 的 T20 和 Maraviroc 或用于丁型肝炎病毒 (HDV) 的 Myrcludex B。这篇综述的重点是针对具有 I 类融合蛋白的高致病性包膜病毒的六螺旋束核心的进入抑制剂，包括逆转录病毒、冠状病毒、甲型流感病毒、副粘病毒和丝状病毒。

关键词: 进入抑制剂，6-HB，I 类融合蛋白，高致病性包膜病毒，COVID-19

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