摘要
活性氧/氮物质 (ROS/RNS) 通过多种机制在生理上产生,尤其是在炎症反应期间。然而,它们的过度生产会导致称为氧化/亚硝化应激的条件的演变,从而导致慢性炎症疾病的发生。查耳酮被认为是一类具有分子模式 1,3-diaryl-2-propen-1-one 的黄酮类化合物。在过去的几年中,查耳酮的抗氧化特性得到了广泛的研究,主要是由于它们能够抑制 ROS/RNS 的产生或清除。本综述展示和讨论了查耳酮的抗氧化活性,重点是炎症反应期间 ROS/RNS 的产生。该文献修订基于查耳酮对不同酶的调节作用,例如超氧化物歧化酶 (SOD)、烟酰胺腺嘌呤二核苷酸磷酸 (NADPH) 氧化酶、过氧化氢酶 (CAT)、髓过氧化物酶 (MPO) 和诱导型一氧化氮合酶 (iNOS),以及清除 ROS/RNS。只要有可能,就会建立构效关系 (SAR)。通过本综述中完成的分析,可以观察到取代基的存在,例如查耳酮支架中的羟基、甲氧基、异戊二烯基和卤素原子经常出现并且可以改善它们的调节活性,即在炎症反应期间产生 ROS/RNS。
关键词: 查耳酮、抗氧化活性、抗炎活性、活性氧、活性氮、炎症。
Current Medicinal Chemistry
Title:Antioxidant Effects of Chalcones during the Inflammatory Response: An Overall Review
Volume: 28 Issue: 37
关键词: 查耳酮、抗氧化活性、抗炎活性、活性氧、活性氮、炎症。
摘要: Reactive oxygen/nitrogen species (ROS/RNS) are produced physiologically by several mechanisms, especially during the inflammatory response. However, their overproduction can lead to the evolution of conditions known as oxidative/nitrosative stress, resulting in the establishment of chronic inflammatory diseases. Chalcones are considered as a class of flavonoids having the molecular pattern 1,3-diaryl-2-propen-1-one. In the last few years, the antioxidant property of chalcones has been extensively studied, mainly due to their ability to inhibit the production or scavenging ROS/RNS. The antioxidant activity of chalcones, focusing on the production of ROS/RNS during the inflammatory response, is demonstrated and discussed in the present review. This literature revision was based on the modulatory effects of chalcones against different enzymes, such as superoxide dismutase (SOD), nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, catalase (CAT), myeloperoxidase (MPO) and inducible nitric oxide synthase (iNOS), and, in the scavenging of ROS/RNS. Whenever possible, the structure-activity relationship (SAR) was established. Through the analysis accomplished in this review, it can be observed that the presence of substituents, e.g. hydroxyl, methoxyl, prenyl, and halogen atoms in the chalcones scaffold, often occurs and can improve their modulatory activities, namely, in the production of ROS/RNS during the inflammatory response.
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Cite this article as:
Antioxidant Effects of Chalcones during the Inflammatory Response: An Overall Review, Current Medicinal Chemistry 2021; 28 (37) . https://dx.doi.org/10.2174/0929867328666210511014949
DOI https://dx.doi.org/10.2174/0929867328666210511014949 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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