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ISSN (Print): 1872-2083
ISSN (Online): 2212-4012

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Review Article

Probiotics/Prebiotics in Viral Respiratory Infections: Implication for Emerging Pathogens

Author(s): Zahra Heidari, Amir Tajbakhsh, Seyed M. Gheibihayat, Afagh Moattari, Vahid Razban, Aydin Berenjian, Amir Savardashtaki* and Manica Negahdaripour *

Volume 15, Issue 2, 2021

Published on: 19 April, 2021

Page: [112 - 136] Pages: 25

DOI: 10.2174/1872208315666210419103742

Price: $65

Abstract

Background: Viral respiratory infections could result in perturbation of the gut microbiota due to a probable cross-talk between lungs and gut microbiota. This can affect pulmonary health and the gastrointestinal system.

Objective: This review aimed to discuss the impact of probiotics/prebiotics and supplements on the prevention and treatment of respiratory infections, especially emerging pathogens.

Methods: The data were searched in PubMed, Scopus, Google Scholar, Google Patents, and The Lens-Patent using keywords of probiotics and viral respiratory infections in the title, abstract, and keywords.

Results: Probiotics consumption could decrease the susceptibility to viral respiratory infections, such as COVID-19 and simultaneously enhance vaccine efficiency in infectious disease prevention through the immune system enhancement. Probiotics improve the gut microbiota and the immune system via regulating the innate system response and production of anti-inflammatory cytokines. Moreover, treatment with probiotics contributes to intestinal homeostasis restitution under antibiotic pressure and decreasing the risk of secondary infections due to viral respiratory infections. Probiotics present varied performances in different conditions; thus, promoting their efficacy through combining with supplements (prebiotics, postbiotics, nutraceuticals, berberine, curcumin, lactoferrin, minerals, and vitamins) is important. Several supplements reported to enhance the probiotics’ efficacy and their mechanisms as well as probiotics- related patents are summarized in this review. Using nanotechnology and microencapsulation techniques can also improve probiotics’ efficiency.

Conclusion: Given the global challenge of COVID-19, probiotic/prebiotic and following nutritional guidelines should be regarded seriously. Additionally, their role as an adjuvant in vaccination for immune response augmentation needs attention.

Keywords: COVID-19, SARS-CoV-2, gut microbiome, microbiota, lung infection, probiotics, prebiotics, nutraceutical.

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[1]
Dhar D, Mohanty A. Gut microbiota and Covid-19- possible link and implications. Virus Res 2020; 285: 198018.
[http://dx.doi.org/10.1016/j.virusres.2020.198018] [PMID: 32430279]
[2]
Dethlefsen L, McFall-Ngai M, Relman DA. An ecological and evolutionary perspective on human-microbe mutualism and disease. Nature 2007; 449(7164): 811-8.
[http://dx.doi.org/10.1038/nature06245] [PMID: 17943117]
[3]
Mousa HA. Prevention and treatment of influenza, influenza-like illness, and common cold by herbal, complementary, and natural therapies. J Evid Based Complementary Altern Med 2017; 22(1): 166-74.
[http://dx.doi.org/10.1177/2156587216641831] [PMID: 27055821]
[4]
Vakili S, Savardashtaki A, Jamalnia S, et al. Laboratory findings of COVID-19 infection are conflicting in different age groups and pregnant women: a literature review. Arch Med Res 2020; 51(7): 603-7.
[http://dx.doi.org/10.1016/j.arcmed.2020.06.007] [PMID: 32571605]
[5]
Nagpal R, Mainali R, Ahmadi S, et al. Gut microbiome and aging: physiological and mechanistic insights. Nutr Healthy Aging 2018; 4(4): 267-85.
[http://dx.doi.org/10.3233/NHA-170030] [PMID: 29951588]
[6]
Tajbakhsh A, Gheibi Hayat SM, Taghizadeh H, et al. COVID-19 and cardiac injury: clinical manifestations, biomarkers, mechanisms, diagnosis, treatment, and follow up. Expert Rev Anti Infect Ther 2021; 19(3): 345-57.
[http://dx.doi.org/10.1080/14787210.2020.1822737] [PMID: 32921216]
[7]
Zolnikova O, Komkova I, Potskherashvili N, Trukhmanov A, Ivashkin V. Application of probiotics for acute respiratory tract infections. Ital J Med 2018; 12(1): 32.
[http://dx.doi.org/10.4081/itjm.2018.931]
[8]
Polack FP, Thomas SJ, Kitchin N, et al. C4591001 clinical trial group. Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine. N Engl J Med 2020; 383(27): 2603-15.
[http://dx.doi.org/10.1056/NEJMoa2034577] [PMID: 33301246]
[9]
Negahdaripour M. The battle against COVID-19: where do we stand now? Iran J Med Sci 2020; 45(2): 81-2.
[PMID: 32210483]
[10]
Mahase E. Covid-19: Novavax vaccine efficacy is 86% against UK variant and 60% against South African variant. BMJ 2021; 372(296): n296.
[http://dx.doi.org/10.1136/bmj.n296] [PMID: 33526412]
[11]
Chung YH, Beiss V, Fiering SN, Steinmetz NF. COVID-19 vaccine frontrunners and their nanotechnology design. ACS Nano 2020; 14(10): 12522-37.
[http://dx.doi.org/10.1021/acsnano.0c07197] [PMID: 33034449]
[12]
Lehtoranta L, Pitkäranta A, Korpela R. Probiotics in respiratory virus infections. Eur J Clin Microbiol Infect Dis 2014; 33(8): 1289-302.
[http://dx.doi.org/10.1007/s10096-014-2086-y] [PMID: 24638909]
[13]
Lehtoranta L, Kalima K, He L, et al. Specific probiotics and virological findings in symptomatic conscripts attending military service in Finland. J Clin Virol 2014; 60(3): 276-81.
[http://dx.doi.org/10.1016/j.jcv.2014.03.021] [PMID: 24793963]
[14]
Reid G, Jass J, Sebulsky MT, McCormick JK. Potential uses of probiotics in clinical practice. Clin Microbiol Rev 2003; 16(4): 658-72.
[http://dx.doi.org/10.1128/CMR.16.4.658-672.2003] [PMID: 14557292]
[15]
Perez-Lopez A, Behnsen J, Nuccio SP, Raffatellu M. Mucosal immunity to pathogenic intestinal bacteria. Nat Rev Immunol 2016; 16(3): 135-48.
[http://dx.doi.org/10.1038/nri.2015.17] [PMID: 26898110]
[16]
Gohil K, Samson R, Dastager S, Dharne M. Probiotics in the prophylaxis of COVID-19: something is better than nothing. 3 Biotech 2021; 11(1): 1.
[17]
Din AU, Mazhar M, Waseem M, et al. SARS-CoV-2 microbiome dysbiosis linked disorders and possible probiotics role. Biomed Pharmacother 2021; 133: 110947.
[http://dx.doi.org/10.1016/j.biopha.2020.110947] [PMID: 33197765]
[18]
Sanders ME, Guarner F, Guerrant R, et al. An update on the use and investigation of probiotics in health and disease. Gut 2013; 62(5): 787-96.
[http://dx.doi.org/10.1136/gutjnl-2012-302504] [PMID: 23474420]
[19]
Horosheva TV, Vodyanoy V, Sorokulova I. Efficacy of Bacillus probiotics in prevention of antibiotic-associated diarrhoea: a randomized, double-blind, placebo-controlled clinical trial. JMM Case Rep 2014; 1(3): 1-6.
[http://dx.doi.org/10.1099/jmmcr.0.004036]
[20]
Szajewska H, Kołodziej M. Systematic review with meta-analysis: Lactobacillus rhamnosus GG in the prevention of antibiotic-associated diarrhoea in children and adults. Aliment Pharmacol Ther 2015; 42(10): 1149-57.
[http://dx.doi.org/10.1111/apt.13404] [PMID: 26365389]
[21]
Gracheva NM, Gavrilov AF, Solov’eva AI, et al. [The efficacy of the new bacterial preparation biosporin in treating acute intestinal infections]. Zh Mikrobiol Epidemiol Immunobiol 1996; (1): 75-7.
[PMID: 8820685]
[22]
Zhao A, Li Z, Ke Y, et al. Dietary diversity among Chinese residents during the COVID-19 outbreak and its associated factors. Nutrients 2020; 12(6): E1699.
[http://dx.doi.org/10.3390/nu12061699] [PMID: 32517210]
[23]
Smits HH, Engering A, van der Kleij D, et al. Selective probiotic bacteria induce IL-10-producing regulatory T cells in vitro by modulating dendritic cell function through dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin. J Allergy Clin Immunol 2005; 115(6): 1260-7.
[http://dx.doi.org/10.1016/j.jaci.2005.03.036] [PMID: 15940144]
[24]
Caballero-Franco C, Keller K, De Simone C, Chadee K. The VSL#3 probiotic formula induces mucin gene expression and secretion in colonic epithelial cells. Am J Physiol Gastrointest Liver Physiol 2007; 292(1): G315-22.
[http://dx.doi.org/10.1152/ajpgi.00265.2006] [PMID: 16973917]
[25]
Aureli P, Capurso L, Castellazzi AM, et al. Probiotics and health: an evidence-based review. Pharmacol Res 2011; 63(5): 366-76.
[http://dx.doi.org/10.1016/j.phrs.2011.02.006] [PMID: 21349334]
[26]
Damjanovic D, Small CL, Jeyanathan M, McCormick S, Xing Z. Immunopathology in influenza virus infection: uncoupling the friend from foe. Clin Immunol 2012; 144(1): 57-69.
[http://dx.doi.org/10.1016/j.clim.2012.05.005] [PMID: 22673491]
[27]
Walker CLF, Rudan I, Liu L, et al. Global burden of childhood pneumonia and diarrhoea. Lancet 2013; 381(9875): 1405-16.
[http://dx.doi.org/10.1016/S0140-6736(13)60222-6] [PMID: 23582727]
[28]
Kassebaum N, Kyu HH, Zoeckler L, et al. Global burden of disease child and adolescent health collaboration. Child and adolescent health from 1990 to 2015: findings from the global burden of diseases, injuries, and risk factors 2015 study. JAMA Pediatr 2017; 171(6): 573-92.
[http://dx.doi.org/10.1001/jamapediatrics.2017.0250] [PMID: 28384795]
[29]
Bingula R, Filaire M, Radosevic-Robin N, et al. Desired turbulence? gut-lung axis, immunity, and lung cancer. J Oncol 2017; 2017: 5035371.
[http://dx.doi.org/10.1155/2017/5035371] [PMID: 29075294]
[30]
Lu R, Zhao X, Li J. Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet 2020; 395: 565-74.
[31]
Belderbos M, Kimpen JL, Bont L. Prenatal prevention of respiratory syncytial virus bronchiolitis. Expert Rev Anti Infect Ther 2011; 9(9): 703-6.
[http://dx.doi.org/10.1586/eri.11.83] [PMID: 21905778]
[32]
Khodamoradi Z, Moghadami M, Lotfi M. Co-infection of coronavirus disease 2019 and influenza a: a report from Iran. Arch Iran Med 2020; 23(4): 239-43.
[http://dx.doi.org/10.34172/aim.2020.04] [PMID: 32271596]
[33]
Kumar D. Corona virus: a review of COVID-19. Eurasian J Med Oncol 2020; 4(1): 8-25.
[34]
Lake MA. What we know so far: COVID-19 current clinical knowledge and research. Clin Med (Lond) 2020; 20(2): 124-7.
[http://dx.doi.org/10.7861/clinmed.2019-coron] [PMID: 32139372]
[35]
Yang X, Yu Y, Xu J, et al. Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study. Lancet Respir Med 2020; 8(5): 475-81.
[http://dx.doi.org/10.1016/S2213-2600(20)30079-5] [PMID: 32105632]
[36]
Askari H, Sanadgol N, Azarnezhad A, et al. Kidney diseases and COVID-19 infection: causes and effect, supportive therapeutics and nutritional perspectives. Heliyon 2021; 7(1): e06008.
[http://dx.doi.org/10.1016/j.heliyon.2021.e06008] [PMID: 33495739]
[37]
Koff WC, Williams MA. Covid-19 and immunity in aging populations - a new research agenda. N Engl J Med 2020; 383(9): 804-5.
[http://dx.doi.org/10.1056/NEJMp2006761] [PMID: 32302079]
[38]
Owji H, Negahdaripour M, Hajighahramani N. Immunotherapeutic approaches to curtail COVID-19. Int Immunopharmacol 2020; 88: 106924.
[http://dx.doi.org/10.1016/j.intimp.2020.106924] [PMID: 32877828]
[39]
Xu K, Cai H, Shen Y, et al. [Management of corona virus disease-19 (COVID-19): the Zhejiang experience]. Zhejiang Da Xue Xue Bao Yi Xue Ban 2020; 49(1): 147-57.
[40]
Gutierrez-Castrellon P, Lopez-Velazquez G, Diaz- Garcia L, et al. Diarrhea in preschool children and Lactobacillus reuteri: a randomized controlled trial. Pediatrics 2014; 133(4): e904-9.
[http://dx.doi.org/10.1542/peds.2013-0652] [PMID: 24639271]
[41]
Tubelius P, Stan V, Zachrisson A. Increasing work- place healthiness with the probiotic Lactobacillus reuteri: a randomised, double-blind placebo-controlled study. Environ Health 2005; 4(1): 25.
[http://dx.doi.org/10.1186/1476-069X-4-25] [PMID: 16274475]
[42]
Keely S, Talley NJ, Hansbro PM. Pulmonary-intestinal cross-talk in mucosal inflammatory disease. Mucosal Immunol 2012; 5(1): 7-18.
[http://dx.doi.org/10.1038/mi.2011.55] [PMID: 22089028]
[43]
Dumas A, Bernard L, Poquet Y, Lugo-Villarino G, Neyrolles O. The role of the lung microbiota and the gut-lung axis in respiratory infectious diseases. Cell Microbiol 2018; 20(12): e12966.
[http://dx.doi.org/10.1111/cmi.12966] [PMID: 30329198]
[44]
Groves HT, Higham SL, Moffatt MF, Cox MJ, Tregoning JS. Respiratory viral infection alters the gut microbiota by inducing inappetence. MBio 2020; 11(1): e03236-19.
[http://dx.doi.org/10.1128/mBio.03236-19] [PMID: 32071269]
[45]
Dickson RP. The microbiome and critical illness. Lancet Respir Med 2016; 4(1): 59-72.
[http://dx.doi.org/10.1016/S2213-2600(15)00427-0] [PMID: 26700442]
[46]
Mosca A, Leclerc M, Hugot JP. Gut microbiota diversity and human diseases: should we reintroduce key predators in our ecosystem? Front Microbiol 2016; 7: 455.
[http://dx.doi.org/10.3389/fmicb.2016.00455] [PMID: 27065999]
[47]
Popova M, Molimard P, Courau S, et al. Beneficial effects of probiotics in upper respiratory tract infections and their mechanical actions to antagonize pathogens. J Appl Microbiol 2012; 113(6): 1305-18.
[http://dx.doi.org/10.1111/j.1365-2672.2012.05394.x] [PMID: 22788970]
[48]
Yan F, Polk DB. Probiotics and immune health. Curr Opin Gastroenterol 2011; 27(6): 496-501.
[http://dx.doi.org/10.1097/MOG.0b013e32834baa4d] [PMID: 21897224]
[49]
Wieërs G, Belkhir L, Enaud R, et al. How probiotics affect the microbiota. Front Cell Infect Microbiol 2020; 9: 454.
[http://dx.doi.org/10.3389/fcimb.2019.00454] [PMID: 32010640]
[50]
Szajewska H, Konarska Z, Kołodziej M. Probiotic bacterial and fungal strains: claims with evidence. Dig Dis 2016; 34(3): 251-9.
[http://dx.doi.org/10.1159/000443359] [PMID: 27028756]
[51]
Vitetta L, Briskey D, Alford H, Hall S, Coulson S. Probiotics, prebiotics and the gastrointestinal tract in health and disease. Inflammopharmacology 2014; 22(3): 135-54.
[http://dx.doi.org/10.1007/s10787-014-0201-4] [PMID: 24633989]
[52]
Hojsak I, Abdović S, Szajewska H, Milosević M, Krznarić Z, Kolacek S. Lactobacillus GG in the prevention of nosocomial gastrointestinal and respiratory tract infections. Pediatrics 2010; 125(5): e1171-7.
[http://dx.doi.org/10.1542/peds.2009-2568] [PMID: 20403940]
[53]
Hojsak I, Snovak N, Abdović S, Szajewska H, Misak Z, Kolacek S. Lactobacillus GG in the prevention of gastrointestinal and respiratory tract infections in children who attend day care centers: a randomized, double-blind, placebo-controlled trial. Clin Nutr 2010; 29(3): 312-6.
[http://dx.doi.org/10.1016/j.clnu.2009.09.008] [PMID: 19896252]
[54]
Infusino F, Marazzato M, Mancone M, et al. Diet supplementation, probiotics, and nutraceuticals in sars-cov-2 infection: a scoping review. Nutrients 2020; 12(6): E1718.
[http://dx.doi.org/10.3390/nu12061718] [PMID: 32521760]
[55]
Di Giacinto C, Marinaro M, Sanchez M, Strober W, Boirivant M. Probiotics ameliorate recurrent Th1-mediated murine colitis by inducing IL-10 and IL-10-dependent TGF-beta-bearing regulatory cells. J Immunol 2005; 174(6): 3237-46.
[http://dx.doi.org/10.4049/jimmunol.174.6.3237] [PMID: 15749854]
[56]
Rioux KP, Fedorak RN. Probiotics in the treatment of inflammatory bowel disease. J Clin Gastroenterol 2006; 40(3): 260-3.
[http://dx.doi.org/10.1097/00004836-200603000-00019] [PMID: 16633133]
[57]
Lorea Baroja M, Kirjavainen PV, Hekmat S, Reid G. Anti-inflammatory effects of probiotic yogurt in inflammatory bowel disease patients. Clin Exp Immunol 2007; 149(3): 470-9.
[http://dx.doi.org/10.1111/j.1365-2249.2007.03434.x] [PMID: 17590176]
[58]
Maldonado Galdeano C, Cazorla SI, Lemme Dumit JM, Vélez E, Perdigón G. Beneficial effects of probiotic consumption on the immune system. Ann Nutr Metab 2019; 74(2): 115-24.
[http://dx.doi.org/10.1159/000496426] [PMID: 30673668]
[59]
Llewellyn A, Foey A. Probiotic modulation of innate cell pathogen sensing and signaling events. Nutrients 2017; 9(10): E1156.
[http://dx.doi.org/10.3390/nu9101156] [PMID: 29065562]
[60]
So JS, Lee CG, Kwon HK, et al. Lactobacillus casei potentiates induction of oral tolerance in experimental arthritis. Mol Immunol 2008; 46(1): 172-80.
[http://dx.doi.org/10.1016/j.molimm.2008.07.038] [PMID: 18804867]
[61]
Rocha-Ramírez LM, Pérez-Solano RA, Castañón-Alonso SL, et al. Probiotic Lactobacillus strains stimulate the inflammatory response and activate human macrophages. J Immunol Res 2017; 2017: 4607491.
[http://dx.doi.org/10.1155/2017/4607491] [PMID: 28758133]
[62]
Thomas CM, Versalovic J. Probiotics-host communication: modulation of signaling pathways in the intestine. Gut Microbes 2010; 1(3): 148-63.
[http://dx.doi.org/10.4161/gmic.1.3.11712] [PMID: 20672012]
[63]
Yamane H, Paul WE. Early signaling events that underlie fate decisions of naive CD4(+) T cells toward distinct T-helper cell subsets. Immunol Rev 2013; 252(1): 12-23.
[http://dx.doi.org/10.1111/imr.12032] [PMID: 23405892]
[64]
Baba N, Samson S, Bourdet-Sicard R, Rubio M, Sarfati M. Commensal bacteria trigger a full dendritic cell maturation program that promotes the expansion of non-Tr1 suppressor T cells. J Leukoc Biol 2008; 84(2): 468-76.
[http://dx.doi.org/10.1189/jlb.0108017] [PMID: 18511576]
[65]
Bermudez-Brito M, Plaza-Díaz J, Muñoz-Quezada S, Gómez-Llorente C, Gil A. Probiotic mechanisms of action. Ann Nutr Metab 2012; 61(2): 160-74.
[http://dx.doi.org/10.1159/000342079] [PMID: 23037511]
[66]
Wang B, Hylwka T, Smieja M, Surrette M, Bowdish DME, Loeb M. Probiotics to prevent respiratory infections in nursing homes: a pilot randomized controlled trial. J Am Geriatr Soc 2018; 66(7): 1346-52.
[http://dx.doi.org/10.1111/jgs.15396] [PMID: 29741754]
[67]
Turner RB, Woodfolk JA, Borish L, et al. Effect of probiotic on innate inflammatory response and viral shedding in experimental rhinovirus infection - a randomised controlled trial. Benef Microbes 2017; 8(2): 207-15.
[http://dx.doi.org/10.3920/BM2016.0160] [PMID: 28343401]
[68]
Shida K, Sato T, Iizuka R, et al. Daily intake of fermented milk with Lactobacillus casei strain Shirota reduces the incidence and duration of upper respiratory tract infections in healthy middle-aged office workers. Eur J Nutr 2017; 56(1): 45-53.
[http://dx.doi.org/10.1007/s00394-015-1056-1] [PMID: 26419583]
[69]
Przemska-Kosicka A, Childs CE, Enani S, et al. Effect of a synbiotic on the response to seasonal influenza vaccination is strongly influenced by degree of immunosenescence. Immun Ageing 2016; 13: 6.
[http://dx.doi.org/10.1186/s12979-016-0061-4] [PMID: 26985232]
[70]
Liu Y, Tran DQ, Rhoads JM. Probiotics in disease prevention and treatment. J Clin Pharmacol 2018; 58(Suppl 10): S164-79.
[71]
Lepargneur JP, Rousseau V. [Protective role of the Doderleïn flora]. J Gynecol Obstet Biol Reprod (Paris) 2002; 31(5): 485-94.
[PMID: 12379833]
[72]
Davani-Davari D, Negahdaripour M, Karimzadeh I, et al. Prebiotics: definition, types, sources, mechanisms, and clinical applications. Foods 2019; 8(3): 92.
[http://dx.doi.org/10.3390/foods8030092] [PMID: 30857316]
[73]
Kleessen B, Sykura B, Zunft HJ, Blaut M. Effects of inulin and lactose on fecal microflora, microbial activity, and bowel habit in elderly constipated persons. Am J Clin Nutr 1997; 65(5): 1397-402.
[http://dx.doi.org/10.1093/ajcn/65.5.1397] [PMID: 9129468]
[74]
Bouhnik Y, Achour L, Paineau D, Riottot M, Attar A, Bornet F. Four-week short chain fructo-oligosaccharides ingestion leads to increasing fecal bifidobacteria and cholesterol excretion in healthy elderly volunteers. Nutr J 2007; 6(1): 42.
[http://dx.doi.org/10.1186/1475-2891-6-42] [PMID: 18053236]
[75]
Keim NL, Martin RJ. Dietary whole grain-microbiota interactions: insights into mechanisms for human health. Adv Nutr 2014; 5(5): 556-7.
[http://dx.doi.org/10.3945/an.114.006536] [PMID: 25469393]
[76]
West NP, Christophersen CT, Pyne DB, et al. Butyrylated starch increases colonic butyrate concentration but has limited effects on immunity in healthy physically active individuals. Exerc Immunol Rev 2013; 19: 102-19.
[PMID: 23977723]
[77]
Schley PD, Field CJ. The immune-enhancing effects of dietary fibres and prebiotics. Br J Nutr 2002; 87(Suppl 2): S221-30.
[78]
Trompette A, Gollwitzer ES, Yadava K, et al. Gut microbiota metabolism of dietary fiber influences allergic airway disease and hematopoiesis. Nat Med 2014; 20(2): 159-66.
[http://dx.doi.org/10.1038/nm.3444] [PMID: 24390308]
[79]
Arslanoglu S, Moro GE, Boehm G. Early supplementation of prebiotic oligosaccharides protects formula-fed infants against infections during the first 6 months of life. J Nutr 2007; 137(11): 2420-4.
[http://dx.doi.org/10.1093/jn/137.11.2420] [PMID: 17951479]
[80]
Gibson GR, Hutkins R, Sanders ME, et al. Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nat Rev Gastroenterol Hepatol 2017; 14(8): 491-502.
[http://dx.doi.org/10.1038/nrgastro.2017.75] [PMID: 28611480]
[81]
Rondanelli M, Faliva MA, Perna S, Giacosa A, Peroni G, Castellazzi AM. Using probiotics in clinical practice: where are we now? a review of existing meta-analyses. Gut Microbes 2017; 8(6): 521-43.
[http://dx.doi.org/10.1080/19490976.2017.1345414] [PMID: 28640662]
[82]
Ahanchian H, Jafari SA, Ansari E, et al. A multi-strain Synbiotic may reduce viral respiratory infections in asthmatic children: a randomized controlled trial. Electron Physician 2016; 8(9): 2833-9.
[http://dx.doi.org/10.19082/2833] [PMID: 27790333]
[83]
Kukkonen K, Savilahti E, Haahtela T, et al. Long-term safety and impact on infection rates of postnatal probiotic and prebiotic (synbiotic) treatment: randomized, double-blind, placebo-controlled trial. Pediatrics 2008; 122(1): 8-12.
[http://dx.doi.org/10.1542/peds.2007-1192] [PMID: 18595980]
[84]
van de Pol MA, Lutter R, Smids BS, Weersink EJ, van der Zee JS. Synbiotics reduce allergen-induced T-helper 2 response and improve peak expiratory flow in allergic asthmatics. Allergy 2011; 66(1): 39-47.
[http://dx.doi.org/10.1111/j.1398-9995.2010.02454.x] [PMID: 20716319]
[85]
Luoto R, Ruuskanen O, Waris M, Kalliomäki M, Salminen S, Isolauri E. Prebiotic and probiotic supplementation prevents rhinovirus infections in preterm infants: a randomized, placebo-controlled trial. J Allergy Clin Immunol 2014; 133(2): 405-13.
[http://dx.doi.org/10.1016/j.jaci.2013.08.020] [PMID: 24131826]
[86]
Cazzola M, Pham-Thi N, Kerihuel JC, Durand H, Bohbot S. Efficacy of a synbiotic supplementation in the prevention of common winter diseases in children: a randomized, double-blind, placebo-controlled pilot study. Ther Adv Respir Dis 2010; 4(5): 271-8.
[http://dx.doi.org/10.1177/1753465810379010] [PMID: 20729255]
[87]
Sergeev VN, Barashkov GN, Gilmutdinova IR, et al. Technology of rehabilitation-preventive nutritional support in coronavirus infection. RU2735723C1, 2020.
[88]
Malagón-Rojas JN, Mantziari A, Salminen S, Szajewska H. Postbiotics for preventing and treating common infectious diseases in children: a systematic review. Nutrients 2020; 12(2): E389.
[http://dx.doi.org/10.3390/nu12020389] [PMID: 32024037]
[89]
Kim KW, Kang SS, Woo SJ, et al. Lipoteichoic acid of probiotic Lactobacillus plantarum attenuates poly I:C-Induced IL-8 production in porcine intestinal epithelial cells. Front Microbiol 2017; 8: 1827.
[http://dx.doi.org/10.3389/fmicb.2017.01827] [PMID: 28983294]
[90]
Frece J, Kos B, Svetec IK, Zgaga Z, Mrsa V, Susković J. Importance of S-layer proteins in probiotic activity of Lactobacillus acidophilus M92. J Appl Microbiol 2005; 98(2): 285-92.
[http://dx.doi.org/10.1111/j.1365-2672.2004.02473.x] [PMID: 15659182]
[91]
Paul D, Manna S, Mandal SM. Antibiotics associated disorders and post-biotics induced rescue in gut health. Curr Pharm Des 2018; 24(7): 821-9.
[http://dx.doi.org/10.2174/1381612824666171227221731] [PMID: 29283050]
[92]
Starosila D, Rybalko S, Varbanetz L, Ivanskaya N, Sorokulova I. Anti-influenza activity of a Bacillus subtilis probiotic strain. Antimicrob Agents Chemother 2017; 61(7): e00539-17.
[http://dx.doi.org/10.1128/AAC.00539-17] [PMID: 28416546]
[93]
Anwar F, Altayb HN, Al-Abbasi FA, Al-Malki AL, Kamal MA, Kumar V. Antiviral effects of probiotic metabolites on COVID-19. J Biomol Struct Dyn 2021; 39(11): 4175-84.
[http://dx.doi.org/10.1080/07391102.2020.1775123] [PMID: 32475223]
[94]
Yang YJ, Sheu BS. Probiotics-containing yogurts suppress Helicobacter pylori load and modify immune response and intestinal microbiota in the Helicobacter pylori-infected children. Helicobacter 2012; 17(4): 297-304.
[http://dx.doi.org/10.1111/j.1523-5378.2012.00941.x] [PMID: 22759330]
[95]
Kumpu M, Kekkonen RA, Korpela R, et al. Effect of live and inactivated Lactobacillus rhamnosus GG on experimentally induced rhinovirus colds: randomised, double blind, placebo-controlled pilot trial. Benef Microbes 2015; 6(5): 631-9.
[http://dx.doi.org/10.3920/BM2014.0164] [PMID: 26322544]
[96]
Villena J, Chiba E, Tomosada Y, et al. Orally administered Lactobacillus rhamnosus modulates the respiratory immune response triggered by the viral pathogen-associated molecular pattern poly(I:C). BMC Immunol 2012; 13: 53.
[http://dx.doi.org/10.1186/1471-2172-13-53] [PMID: 22989047]
[97]
Chen G, Wu D, Guo W, et al. Clinical and immunological features of severe and moderate coronavirus disease 2019. J Clin Invest 2020; 130(5): 2620-9.
[http://dx.doi.org/10.1172/JCI137244] [PMID: 32217835]
[98]
Tong JL, Ran ZH, Shen J, Zhang CX, Xiao SD. Meta-analysis: the effect of supplementation with probiotics on eradication rates and adverse events during Helicobacter pylori eradication therapy. Aliment Pharmacol Ther 2007; 25(2): 155-68.
[http://dx.doi.org/10.1111/j.1365-2036.2006.03179.x] [PMID: 17229240]
[99]
Hoveyda N, Heneghan C, Mahtani KR, Perera R, Roberts N, Glasziou P. A systematic review and meta-analysis: probiotics in the treatment of irritable bowel syndrome. BMC Gastroenterol 2009; 9: 15.
[http://dx.doi.org/10.1186/1471-230X-9-15] [PMID: 19220890]
[100]
Deshpande G, Rao S, Patole S. Probiotics for prevention of necrotising enterocolitis in preterm neonates with very low birthweight: a systematic review of randomised controlled trials. Lancet 2007; 369(9573): 1614-20.
[http://dx.doi.org/10.1016/S0140-6736(07)60748-X] [PMID: 17499603]
[101]
Elahi B, Nikfar S, Derakhshani S, Vafaie M, Abdollahi M. On the benefit of probiotics in the management of pouchitis in patients underwent ileal pouch anal anastomosis: a meta-analysis of controlled clinical trials. Dig Dis Sci 2008; 53(5): 1278-84.
[http://dx.doi.org/10.1007/s10620-007-0006-z] [PMID: 17940902]
[102]
Villena J, Medina M, Vintiñi E, Alvarez S. Stimulation of respiratory immunity by oral administration of Lactococcus lactis. Can J Microbiol 2008; 54(8): 630-8.
[http://dx.doi.org/10.1139/W08-052] [PMID: 18772925]
[103]
Weiss JR, Tessema B, Brown SM. Complementary and integrative treatments: upper respiratory infection. Otolaryngol Clin North Am 2013; 46(3): 335-44.
[http://dx.doi.org/10.1016/j.otc.2012.12.007] [PMID: 23764813]
[104]
VidyaLaxme B, Rovetto A, Grau R, Agrawal R. Synergistic effects of probiotic Leuconostoc mesenteroides and Bacillus subtilis in malted ragi (Eleucine corocana) food for antagonistic activity against V. cholerae and other beneficial properties. J Food Sci Technol 2014; 51(11): 3072-82.
[http://dx.doi.org/10.1007/s13197-012-0834-5] [PMID: 26396299]
[105]
Ridwan BU, Koning CJ, Besselink MG, et al. Antimicrobial activity of a multispecies probiotic (Ecologic 641) against pathogens isolated from infected pancreatic necrosis. Lett Appl Microbiol 2008; 46(1): 61-7.
[PMID: 17944834]
[106]
Lin JS, Chiu YH, Lin NT, et al. Different effects of probiotic species/strains on infections in preschool children: a double-blind, randomized, controlled study. Vaccine 2009; 27(7): 1073-9.
[http://dx.doi.org/10.1016/j.vaccine.2008.11.114] [PMID: 19114073]
[107]
Kim J, Muhammad N, Jhun BH, Yoo J-W. Probiotic delivery systems: a brief overview. J Pharm Investig 2016; 46(4): 377-86.
[http://dx.doi.org/10.1007/s40005-016-0259-7]
[108]
Muthukumarasamy P, Allan-Wojtas P, Holley RA. Stability of Lactobacillus reuteri in different types of microcapsules. J Food Sci 2006; 71(1): M20-4.
[http://dx.doi.org/10.1111/j.1365-2621.2006.tb12395.x]
[109]
Choi JW, Kim KH, Cho YM, Kim SH. Current epidemiological situation of Middle East respiratory syndrome coronavirus clusters and implications for public health response in South Korea. J Korean Med Assoc 2015; 58(6): 487.
[http://dx.doi.org/10.5124/jkma.2015.58.6.487]
[110]
Ding WK, Shah NP. An improved method of microencapsulation of probiotic bacteria for their stability in acidic and bile conditions during storage. J Food Sci 2009; 74(2): M53-61.
[http://dx.doi.org/10.1111/j.1750-3841.2008.01030.x] [PMID: 19323758]
[111]
Sun W, Griffiths MW. Survival of bifidobacteria in yogurt and simulated gastric juice following immobilization in gellan-xanthan beads. Int J Food Microbiol 2000; 61(1): 17-25.
[http://dx.doi.org/10.1016/S0168-1605(00)00327-5] [PMID: 11028956]
[112]
Levy M, Kolodziejczyk AA, Thaiss CA, Elinav E. Dysbiosis and the immune system. Nat Rev Immunol 2017; 17(4): 219-32.
[http://dx.doi.org/10.1038/nri.2017.7] [PMID: 28260787]
[113]
King S, Tancredi D, Lenoir-Wijnkoop I, et al. Does probiotic consumption reduce antibiotic utilization for common acute infections? A systematic review and meta-analysis. Eur J Public Health 2019; 29(3): 494-9.
[http://dx.doi.org/10.1093/eurpub/cky185] [PMID: 30219897]
[114]
Round JL, Mazmanian SK. The gut microbiota shapes intestinal immune responses during health and disease. Nat Rev Immunol 2009; 9(5): 313-23.
[http://dx.doi.org/10.1038/nri2515] [PMID: 19343057]
[115]
Costello EK, Stagaman K, Dethlefsen L, Bohannan BJ, Relman DA. The application of ecological theory toward an understanding of the human microbiome. Science 2012; 336(6086): 1255-62.
[http://dx.doi.org/10.1126/science.1224203] [PMID: 22674335]
[116]
Hendaus MA, Jomha FA, Alhammadi AH. Virus-induced secondary bacterial infection: a concise review. Ther Clin Risk Manag 2015; 11: 1265-71.
[http://dx.doi.org/10.2147/TCRM.S87789] [PMID: 26345407]
[117]
Walzl G, Tafuro S, Moss P, Openshaw PJ, Hussell T. Influenza virus lung infection protects from respiratory syncytial virus-induced immunopathology. J Exp Med 2000; 192(9): 1317-26.
[http://dx.doi.org/10.1084/jem.192.9.1317] [PMID: 11067880]
[118]
Brundage JF, Shanks GD. Deaths from bacterial pneumonia during 1918-19 influenza pandemic. Emerg Infect Dis 2008; 14(8): 1193-9.
[http://dx.doi.org/10.3201/eid1408.071313] [PMID: 18680641]
[119]
Hanada S, Pirzadeh M, Carver KY, Deng JC. Respiratory viral infection-induced microbiome alterations and secondary bacterial pneumonia. Front Immunol 2018; 9(2640): 2640.
[http://dx.doi.org/10.3389/fimmu.2018.02640] [PMID: 30505304]
[120]
Andrej E. The problem of bacterial complications post respiratory viral infections. Res J Microbiol 2018; 5(1): 12-21.
[121]
Morris DE, Cleary DW, Clarke SC. Secondary bacterial infections associated with influenza pandemics. Front Microbiol 2017; 8: 1041.
[http://dx.doi.org/10.3389/fmicb.2017.01041] [PMID: 28690590]
[122]
Imani FA, Mahmoodzadeh H, Nourani MR, Khani S, Alavian SM. Probiotic as a novel treatment strategy against liver disease. Hepat Mon 2013; 13(2): e7521.
[http://dx.doi.org/10.5812/hepatmon.7521] [PMID: 23610585]
[123]
Karlsson C, Ahrné S, Molin G, et al. Probiotic therapy to men with incipient arteriosclerosis initiates increased bacterial diversity in colon: a randomized controlled trial. Atherosclerosis 2010; 208(1): 228-33.
[http://dx.doi.org/10.1016/j.atherosclerosis.2009.06.019] [PMID: 19608185]
[124]
Forsythe P. Probiotics and lung diseases. Chest 2011; 139(4): 901-8.
[http://dx.doi.org/10.1378/chest.10-1861] [PMID: 21467057]
[125]
Chen Z, Lv Y, Xu H, Deng L. Herbal Medicine, Gut Microbiota, and COVID-19. Front Pharmacol 2021; 12: 646560.
[126]
Romano L, Bilotta F, Dauri M, et al. Short Report - Medical nutrition therapy for critically ill patients with COVID-19. Eur Rev Med Pharmacol Sci 2020; 24(7): 4035-9.
[PMID: 32329880]
[127]
Di Pierro F. A possible probiotic (S. salivarius K12) approach to improve oral and lung microbiotas and raise defenses against SAR S-CoV-2. Minerva Med 2020; 111(3): 281-3.
[http://dx.doi.org/10.23736/S0026-4806.20.06570-2] [PMID: 32255312]
[128]
Burton JP, Cowley S, Simon RR, McKinney J, Wescombe PA, Tagg JR. Evaluation of safety and human tolerance of the oral probiotic Streptococcus salivarius K12: a randomized, placebo-controlled, double-blind study. Food Chem Toxicol 2011; 49(9): 2356-64.
[http://dx.doi.org/10.1016/j.fct.2011.06.038] [PMID: 21722694]
[129]
Nassira L, Ishaq B. Probiotic which cures covid 19 patients by transfer of natural passive immunity from immunised cows. WO 2020/143892 A2, 2020.
[130]
Fonollá J, Gracián C, Maldonado-Lobón JA, et al. Effects of Lactobacillus coryniformis K8 CECT5711 on the immune response to influenza vaccination and the assessment of common respiratory symptoms in elderly subjects: a randomized controlled trial. Eur J Nutr 2019; 58(1): 83-90.
[http://dx.doi.org/10.1007/s00394-017-1573-1] [PMID: 29124387]
[131]
Ningyi J, Chang L, Maopeng W, et al. Recombinant plant lactic acid bacteria for expressing SARS-CoV-2S gene and its preparation method. CN111518740A, 2020.
[132]
Oelschlaeger TA. Mechanisms of probiotic actions - A review. Int J Med Microbiol 2010; 300(1): 57-62.
[http://dx.doi.org/10.1016/j.ijmm.2009.08.005] [PMID: 19783474]
[133]
Seon SC, Na YH, Tack HW. Composition for preventing and treating influenza viruses comprising lactic acid bacteria as active ingredients. WO2017/119665A1, 2017.
[134]
Park MK, Ngo V, Kwon YM, et al. Lactobacillus plantarum DK119 as a probiotic confers protection against influenza virus by modulating innate immunity. PLoS One 2013; 8(10): e75368.
[http://dx.doi.org/10.1371/journal.pone.0075368] [PMID: 24124485]
[135]
Hayakawa K, Kodoi R, Kunito N, Yamura T, Yasuda T. Intestinal immune power increasing agent containing lactobacillus having iga antibody production improving action. JP2008201708A, 2008.
[136]
Yamura T, Kikuchi Y, Fukutome S, Hamada K, Abe N, Kasuya K. Prophylactic/therapeutic agent for viral disease JP2013053089A, 2011.
[137]
Kikuchi Y, Kunitoh-Asari A, Hayakawa K, et al. Oral administration of Lactobacillus plantarum strain AYA enhances IgA secretion and provides survival protection against influenza virus infection in mice. PLoS One 2014; 9(1): e86416.
[http://dx.doi.org/10.1371/journal.pone.0086416] [PMID: 24466081]
[138]
Min-jung J, Kyung-eun H, Ki-deok P, Kim J, Kim H, Yong-pil H. Composition for prevention or treatment of respiratory diseases or inflammation induced by particulate matter comprising novel lactic acid bacteria. KR102165929B1, 2020.
[139]
Wu C, Chen X, Cai Y, et al. Risk factors associated with acute respiratory distress syndrome and death in patients with coronavirus disease 2019 pneumonia in Wuhan, China. JAMA Intern Med 2020; 180(7): 934-43.
[140]
Aiello A, Farzaneh F, Candore G, et al. Immunosenescence and its hallmarks: how to oppose aging strategically? a review of potential options for therapeutic intervention. Front Immunol 2019; 10(2247): 2247.
[http://dx.doi.org/10.3389/fimmu.2019.02247] [PMID: 31608061]
[141]
Salazar N, Arboleya S, Fernández-Navarro T, de Los Reyes-Gavilán CG, Gonzalez S, Gueimonde M. Age-associated changes in gut microbiota and dietary components related with the immune system in adulthood and old age: a cross-sectional study. Nutrients 2019; 11(8): E1765.
[http://dx.doi.org/10.3390/nu11081765] [PMID: 31370376]
[142]
Boge T, Rémigy M, Vaudaine S, Tanguy J, Bourdet-Sicard R, van der Werf S. A probiotic fermented dairy drink improves antibody response to influenza vaccination in the elderly in two randomised controlled trials. Vaccine 2009; 27(41): 5677-84.
[http://dx.doi.org/10.1016/j.vaccine.2009.06.094] [PMID: 19615959]
[143]
Bosch M, Méndez M, Pérez M, Farran A, Fuentes MC, Cuñé J. Lactobacillus plantarum CECT7315 and CECT7316 stimulate immunoglobulin production after influenza vaccination in elderly. Nutr Hosp 2012; 27(2): 504-9.
[PMID: 22732975]
[144]
Langkamp-Henken B, Wood SM, Herlinger-Garcia KA, et al. Nutritional formula improved immune profiles of seniors living in nursing homes. J Am Geriatr Soc 2006; 54(12): 1861-70.
[http://dx.doi.org/10.1111/j.1532-5415.2006.00982.x] [PMID: 17198491]
[145]
Langkamp-Henken B, Bender BS, Gardner EM, et al. Nutritional formula enhanced immune function and reduced days of symptoms of upper respiratory tract infection in seniors. J Am Geriatr Soc 2004; 52(1): 3-12.
[http://dx.doi.org/10.1111/j.1532-5415.2004.52003.x] [PMID: 14687308]
[146]
Jayawardena R, Sooriyaarachchi P, Chourdakis M, Jeewandara C, Ranasinghe P. Enhancing immunity in viral infections, with special emphasis on COVID-19: a review. Diabetes Metab Syndr 2020; 14(4): 367-82.
[http://dx.doi.org/10.1016/j.dsx.2020.04.015] [PMID: 32334392]
[147]
Morais AHA, Passos TS, Maciel BLL, da Silva- Maia JK. Can probiotics and diet promote beneficial immune modulation and purine control in coronavirus infection? Nutrients 2020; 12(6): E1737.
[http://dx.doi.org/10.3390/nu12061737] [PMID: 32532069]
[148]
Doron S, Snydman DR. Risk and safety of probiotics. Clin Infect Dis 2015; 60(Suppl 2): S129-34.
[http://dx.doi.org/10.1093/cid/civ085]
[149]
Feng Z, Wang Y, Qi W. The small intestine, an underestimated site of SARS-CoV-2 infection: from red queen effect to probiotics. Preprints 2020; 74: 2020030161.
[http://dx.doi.org/10.20944/preprints202003.0161.v1]
[150]
Vitetta L, Saltzman ET, Thomsen M, Nikov T, Hall S. Adjuvant probiotics and the intestinal microbiome: enhancing vaccines and immunotherapy outcomes. Vaccines (Basel) 2017; 5(4): 50.
[http://dx.doi.org/10.3390/vaccines5040050] [PMID: 29232932]
[151]
Baron M. A patented strain of Bacillus coagulans increased immune response to viral challenge. Postgrad Med 2009; 121(2): 0032-5481.
[152]
Gleeson M, Bishop NC, Struszczak L. Effects of Lactobacillus casei Shirota ingestion on common cold infection and herpes virus antibodies in endurance athletes: a placebo-controlled, randomized trial. Eur J Appl Physiol 2016; 116(8): 1555-63.
[http://dx.doi.org/10.1007/s00421-016-3415-x] [PMID: 27294502]
[153]
Jespersen L, Tarnow I, Eskesen D, et al. Effect of Lactobacillus paracasei subsp. paracasei, L. casei 431 on immune response to influenza vaccination and upper respiratory tract infections in healthy adult volunteers: a randomized, double-blind, placebo-controlled, parallel-group study. Am J Clin Nutr 2015; 101(6): 1188-96.
[http://dx.doi.org/10.3945/ajcn.114.103531] [PMID: 25926507]
[154]
Kumpu M, Lehtoranta L, Roivainen M, et al. The use of the probiotic Lactobacillus rhamnosus GG and viral findings in the nasopharynx of children attending day care. J Med Virol 2013; 85(9): 1632-8.
[http://dx.doi.org/10.1002/jmv.23623] [PMID: 23794458]
[155]
Lehtinen MJ, Hibberd AA, Männikkö S, et al. Nasal microbiota clusters associate with inflammatory response, viral load, and symptom severity in experimental rhinovirus challenge. Sci Rep 2018; 8(1): 11411.
[http://dx.doi.org/10.1038/s41598-018-29793-w] [PMID: 30061588]
[156]
Tapiovaara L, Kumpu M, Mäkivuokko H, et al. Human rhinovirus in experimental infection after peroral Lactobacillus rhamnosus GG consumption, a pilot study. Int Forum Allergy Rhinol 2016; 6(8): 848-53.
[http://dx.doi.org/10.1002/alr.21748] [PMID: 26990147]
[157]
Winkler P, de Vrese M, Laue Ch, Schrezenmeir J. Effect of a dietary supplement containing probiotic bacteria plus vitamins and minerals on common cold infections and cellular immune parameters. Int J Clin Pharmacol Ther 2005; 43(7): 318-26.
[http://dx.doi.org/10.5414/CPP43318] [PMID: 16035374]
[158]
Zhang H, Yeh C, Jin Z, et al. Prospective study of probiotic supplementation results in immune stimulation and improvement of upper respiratory infection rate. Synth Syst Biotechnol 2018; 3(2): 113-20.
[http://dx.doi.org/10.1016/j.synbio.2018.03.001] [PMID: 29900424]
[159]
Li KL, Wang BZ, Li ZP, Li YL, Liang JJ. Alterations of intestinal flora and the effects of probiotics in children with recurrent respiratory tract infection. World J Pediatr 2019; 15(3): 255-61.
[http://dx.doi.org/10.1007/s12519-019-00248-0] [PMID: 31020541]
[160]
Berggren A, Lazou Ahrén I, Larsson N, Önning G. Randomised, double-blind and placebo-controlled study using new probiotic lactobacilli for strengthening the body immune defence against viral infections. Eur J Nutr 2011; 50(3): 203-10.
[http://dx.doi.org/10.1007/s00394-010-0127-6] [PMID: 20803023]
[161]
de Vrese M, Winkler P, Rautenberg P, et al. Probiotic bacteria reduced duration and severity but not the incidence of common cold episodes in a double blind, randomized, controlled trial. Vaccine 2006; 24(44-46): 6670-4.
[http://dx.doi.org/10.1016/j.vaccine.2006.05.048] [PMID: 16844267]
[162]
Akatsu H, Iwabuchi N, Xiao JZ, et al. Clinical effects of probiotic Bifidobacterium longum BB536 on immune function and intestinal microbiota in elderly patients receiving enteral tube feeding. JPEN J Parenter Enteral Nutr 2013; 37(5): 631-40.
[http://dx.doi.org/10.1177/0148607112467819] [PMID: 23192454]
[163]
Harata G, He F, Hiruta N, et al. Intranasal administration of Lactobacillus rhamnosus GG protects mice from H1N1 influenza virus infection by regulating respiratory immune responses. Lett Appl Microbiol 2010; 50(6): 597-602.
[http://dx.doi.org/10.1111/j.1472-765X.2010.02844.x] [PMID: 20438620]
[164]
Lee YN, Youn HN, Kwon JH, et al. Sublingual administration of Lactobacillus rhamnosus affects respiratory immune responses and facilitates protection against influenza virus infection in mice. Antiviral Res 2013; 98(2): 284-90.
[http://dx.doi.org/10.1016/j.antiviral.2013.03.013] [PMID: 23523767]
[165]
Mahooti M, Abdolalipour E, Salehzadeh A, Mohebbi SR, Gorji A, Ghaemi A. Immunomodulatory and prophylactic effects of Bifidobacterium bifidum probiotic strain on influenza infection in mice. World J Microbiol Biotechnol 2019; 35(6): 91.
[http://dx.doi.org/10.1007/s11274-019-2667-0] [PMID: 31161259]
[166]
Percopo CM, Rice TA, Brenner TA, et al. Immunobiotic Lactobacillus administered post-exposure averts the lethal sequelae of respiratory virus infection. Antiviral Res 2015; 121(121): 109-19.
[http://dx.doi.org/10.1016/j.antiviral.2015.07.001] [PMID: 26145728]
[167]
Tomosada Y, Chiba E, Zelaya H, et al. Nasally administered Lactobacillus rhamnosus strains differentially modulate respiratory antiviral immune responses and induce protection against respiratory syncytial virus infection. BMC Immunol 2013; 14: 40.
[http://dx.doi.org/10.1186/1471-2172-14-40] [PMID: 23947615]
[168]
Jung YJ, Lee YT, Ngo VL, et al. Heat-killed Lactobacillus casei confers broad protection against influenza A virus primary infection and develops heterosubtypic immunity against future secondary infection. Sci Rep 2017; 7(1): 17360.
[http://dx.doi.org/10.1038/s41598-017-17487-8] [PMID: 29234060]
[169]
Iovino L, Mazziotta F, Carulli G, et al. High-dose zinc oral supplementation after stem cell transplantation causes an increase of TRECs and CD4+ naïve lymphocytes and prevents TTV reactivation. Leuk Res 2018; 70: 20-4.
[http://dx.doi.org/10.1016/j.leukres.2018.04.016] [PMID: 29747074]
[170]
Girodon F, Galan P, Monget AL, et al. Impact of trace elements and vitamin supplementation on immunity and infections in institutionalized elderly patients: a randomized controlled trial. MIN. VIT. AOX. geriatric network. Arch Intern Med 1999; 159(7): 748-54.
[http://dx.doi.org/10.1001/archinte.159.7.748] [PMID: 10218756]
[171]
Broome CS, McArdle F, Kyle JA, et al. An increase in selenium intake improves immune function and poliovirus handling in adults with marginal selenium status. Am J Clin Nutr 2004; 80(1): 154-62.
[http://dx.doi.org/10.1093/ajcn/80.1.154] [PMID: 15213043]
[172]
Ivory K, Prieto E, Spinks C, et al. Selenium supplementation has beneficial and detrimental effects on immunity to influenza vaccine in older adults. Clin Nutr 2017; 36(2): 407-15.
[http://dx.doi.org/10.1016/j.clnu.2015.12.003] [PMID: 26803169]
[173]
Chen Y, Zhang J, Ge X, Du J, Deb DK, Li YC. Vitamin D receptor inhibits nuclear factor κB activation by interacting with IκB kinase β protein. J Biol Chem 2013; 288(27): 19450-8.
[http://dx.doi.org/10.1074/jbc.M113.467670] [PMID: 23671281]
[174]
Martineau AR, Jolliffe DA, Hooper RL, et al. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ 2017; 356: i6583.
[http://dx.doi.org/10.1136/bmj.i6583] [PMID: 28202713]
[175]
Jones ML, Martoni CJ, Prakash S. Oral supplementation with probiotic L. reuteri NCIMB 30242 increases mean circulating 25-hydroxyvitamin D: a post hoc analysis of a randomized controlled trial. J Clin Endocrinol Metab 2013; 98(7): 2944-51.
[http://dx.doi.org/10.1210/jc.2012-4262] [PMID: 23609838]
[176]
Shang M, Sun J. Vitamin D/VDR, probiotics, and gastrointestinal diseases. Curr Med Chem 2017; 24(9): 876-87.
[http://dx.doi.org/10.2174/0929867323666161202150008] [PMID: 27915988]
[177]
Garaiova I, Muchová J, Nagyová Z, et al. Probiotics and vitamin C for the prevention of respiratory tract infections in children attending preschool: a randomised controlled pilot study. Eur J Clin Nutr 2015; 69(3): 373-9.
[http://dx.doi.org/10.1038/ejcn.2014.174] [PMID: 25205320]
[178]
Wu D, Yang XO. TH17 responses in cytokine storm of COVID-19: An emerging target of JAK2 inhibitor Fedratinib. J Microbiol Immunol Infect 2020; 53(3): 368-70.
[http://dx.doi.org/10.1016/j.jmii.2020.03.005] [PMID: 32205092]
[179]
De Lorenzo A, Costacurta M, Merra G, et al. Can psychobiotics intake modulate psychological profile and body composition of women affected by normal weight obese syndrome and obesity? A double blind randomized clinical trial. J Transl Med 2017; 15(1): 135.
[http://dx.doi.org/10.1186/s12967-017-1236-2] [PMID: 28601084]
[180]
Masaki T, Kojima T, Okabayashi T, et al. A nuclear factor-κB signaling pathway via protein kinase C δ regulates replication of respiratory syncytial virus in polarized normal human nasal epithelial cells. Mol Biol Cell 2011; 22(13): 2144-56.
[http://dx.doi.org/10.1091/mbc.e10-11-0875] [PMID: 21562222]
[181]
Obata K, Kojima T, Masaki T, et al. Curcumin prevents replication of respiratory syncytial virus and the epithelial responses to it in human nasal epithelial cells. PLoS One 2013; 8(9): e70225.
[http://dx.doi.org/10.1371/journal.pone.0070225] [PMID: 24058438]
[182]
Wang H, Zhu C, Ying Y, Luo L, Huang D, Luo Z. Metformin and berberine, two versatile drugs in treatment of common metabolic diseases. Oncotarget 2017; 9(11): 10135-46.
[http://dx.doi.org/10.18632/oncotarget.20807] [PMID: 29515798]
[183]
Zhang W, Xu JH, Yu T, Chen QK. Effects of berberine and metformin on intestinal inflammation and gut microbiome composition in db/db mice. Biomed Pharmacother 2019; 118: 109131.
[http://dx.doi.org/10.1016/j.biopha.2019.109131] [PMID: 31545226]
[184]
Markowiak P, Śliżewska K. Effects of probiotics, prebiotics, and synbiotics on human health. Nutrients 2017; 9(9): E1021.
[http://dx.doi.org/10.3390/nu9091021] [PMID: 28914794]
[185]
Eslamparast T, Poustchi H, Zamani F, Sharafkhah M, Malekzadeh R, Hekmatdoost A. Synbiotic supplementation in nonalcoholic fatty liver disease: a randomized, double-blind, placebo-controlled pilot study. Am J Clin Nutr 2014; 99(3): 535-42.
[http://dx.doi.org/10.3945/ajcn.113.068890] [PMID: 24401715]
[186]
Kruzel ML, Zimecki M, Actor JK. Lactoferrin in a context of inflammation-induced pathology. Front Immunol 2017; 8: 1438.
[http://dx.doi.org/10.3389/fimmu.2017.01438] [PMID: 29163511]
[187]
Hwang SA, Kruzel ML, Actor JK. Lactoferrin augments BCG vaccine efficacy to generate T helper response and subsequent protection against challenge with virulent Mycobacterium tuberculosis. Int Immunopharmacol 2005; 5(3): 591-9.
[http://dx.doi.org/10.1016/j.intimp.2004.11.006] [PMID: 15683854]

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