摘要
存在于多个分子中的喹啉环具有多种生物活性。因此，该环存在于临床前和临床研究中几种候选药物的结构组成中；因此，有必要汇总这些结果以促进新药的设计。出于这个原因，本综述选择了一些化合物的活性进行检查，例如抗疟、抗菌、抗癌、抗炎、抗糖尿病、抗风湿和抗病毒活性。所选科学文章的所有出版物都在 2000 年至 2020 年之间发表。除了介绍一些天然和合成化合物的结构及其活性外，我们还列出了含有喹啉核的抗疟药物的 III 期和 IV 期临床研究和 III 期羟氯喹和氯喹的临床研究，以评估它们在 COVID-19 中的可能作用。最后，我们回顾了一些作用机制，以及一些喹啉衍生物的副作用。
关键词: 临床试验，喹啉环，抗疟药，COVID-19，药理学，氯喹。
图形摘要
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