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Current Organic Synthesis

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ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

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Review Article

Barbiturates: A Review of Synthesis and Antimicrobial Research Progress

Author(s): Madhvi, Divya Utreja* and Shivali Sharma

Volume 19, Issue 1, 2022

Published on: 14 April, 2021

Page: [31 - 55] Pages: 25

DOI: 10.2174/1570179418666210414104857

Price: $65

Abstract

Background: Barbituric acid and its derivatives have gained significant attention for several years as an indispensable class of compounds in the pharmaceutical industry due to their various biological activities, such as anticonvulsants, hypnotics, anti-diabetic, antiviral, anti-AIDS, anti-cancer, anti-microbial, and antioxidant, etc. A plethora of studies has shed light on the properties, synthesis, and reactivity of these compounds. The depiction of multiple biological activities by barbiturates compelled us, and by virtue of which herein we have mediated over the progress of synthesis of numerous kinds of compounds derived from barbituric acid with well-known and typical examples from 2016 to the present.

Objectives: This review focuses on the advancements in methods of synthesis of barbituric acid derivatives and their applications as antimicrobial agents.

Conclusion: This review will help future researchers to analyze the previous studies and explore new compounds for the development of efficient antimicrobial drugs.

Keywords: Barbituric acid, heterocyclic, antimicrobial, antibacterial, antifungal, barbituric and thiobarbituric acids derivatives.

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