摘要
纳米医学是一个新兴领域,它利用纳米技术概念进行开创性的治疗和诊断。与临床实验室诊断中的传统系统相比,用于肿瘤标志物的比色传感器显示出有趣的优势。基于比色免疫测定的方法显示出即将到来的结果,因为目标癌症标记物以高灵敏度确定,但不使用先进/昂贵的技术,通过轻松的光学颜色变化。此外,比色生物传感器具有以高灵敏度快速检测生物体液中蛋白质的潜力,预计它们将在肿瘤诊断中发挥越来越重要的作用。我们回顾了(涵盖 2015-2020 年期间)基于比色传感策略使用纳米结构材料(高效酶模拟物、人工酶或纳米酶)检测生物体液中不同肿瘤抗原的各种研究。具体而言,我们重点介绍了比色免疫传感器构建方面的最新进展和努力。比色免疫传感器大致可分为两大类:基于过渡金属纳米酶的传感和基于贵金属纳米酶的传感。
关键词: 肿瘤标志物、酶模拟物、人工酶、纳米酶、纳米颗粒、比色法、纳米医学、临床分析。
Current Medicinal Chemistry
Title:A Review on Colorimetric Sensing of Tumor Markers Based on Enzyme-Mimicking Nanomaterials
Volume: 28 Issue: 30
关键词: 肿瘤标志物、酶模拟物、人工酶、纳米酶、纳米颗粒、比色法、纳米医学、临床分析。
摘要: Nanomedicine is an arising field that exploits nanotechnology concepts for pioneered therapy and diagnostics. Colorimetric sensors for tumor markers have displayed interesting benefits compared to conventional systems in clinical laboratory diagnosis. Colorimetric immunoassay-based approaches show up-and-coming results since the goal cancer marker is determined with high sensitivity but without the utilization of advanced/- expensive techniques through an effortless optical color change. Also, colorimetric biosensor has the potential to detect proteins in biological fluids swiftly with high sensitivity, and they are anticipated to play a progressively serious role in tumor diagnosis. We reviewed (covering the period 2015-2020) various studies based on colorimetric sensing strategy using nanostructured materials (highly efficient enzyme mimics, artificial enzymes or nanozymes) to detect different tumor antigens in biological fluids. Specifically, we highlighted the recent progress and efforts in the construction of colorimetric immunosensors. Colorimetric immunosensors can be roughly divided into two main categories: transition metal nanozyme-based sensing and noble metal nanozyme-based sensing.
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Cite this article as:
A Review on Colorimetric Sensing of Tumor Markers Based on Enzyme-Mimicking Nanomaterials, Current Medicinal Chemistry 2021; 28 (30) . https://dx.doi.org/10.2174/0929867328666210412122604
DOI https://dx.doi.org/10.2174/0929867328666210412122604 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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