摘要
背景:癌症干细胞 (CSC) 在肿瘤发展中的核心作用已扩展到解释多种肿瘤学现象,例如临床中的多药耐药、转移和肿瘤复发。由于ATP结合盒式转运蛋白和抗凋亡因子的表达增强,G0期停滞和自我更新能力强,CSCs对临床抗癌药物具有高度耐药性。因此,发现可以有效根除癌症干细胞的新候选药物在癌症治疗中提供了有希望的结果。 目的:天然产物及其合成类似物是生物活性化合物的丰富来源,其中一些已被公认为有效的 CSC 杀手。我们的目标是提供一系列最近发现的天然产物,这些产物抑制了小侵袭性 CSC 群体的存活,并在化疗中对抗这些细胞的耐药性。 结果:这些抗 CSCs 天然产物包括黄酮类、芪类、醌类、萜类、聚酮类抗生素、类固醇和生物碱。在本综述中,我们强调了天然产物及其衍生物对 CSC 增殖和耐药性的治疗潜力、它们的工作机制和相关的构效关系。 结论:同时,在本次调查中,具有不同细胞靶点的几种天然产物,如萘醌紫草素和二苯乙烯白藜芦醇,被认为是未来发展的有前途的先导化合物。
关键词: 癌症干细胞、化疗、多药耐药性、天然产物、黄酮类化合物、芪类、萘醌类、紫草素、白藜芦醇、SARs。
Current Medicinal Chemistry
Title:Natural Products Targeting Cancer Stem Cells: A Revisit
Volume: 28 Issue: 33
关键词: 癌症干细胞、化疗、多药耐药性、天然产物、黄酮类化合物、芪类、萘醌类、紫草素、白藜芦醇、SARs。
摘要:
Background: The proposed central role of cancer stem cells (CSCs) in tumor development has been extended to explain the diverse oncologic phenomena such as multidrug resistance, metastasis and tumor recurrence in clinics. Due to the enhanced expression of ATP-binding cassette transporters and anti-apoptotic factors, stagnation on G0 phase and the strong ability of self-renewal, the CSCs were highly resistant to clinical anticancer drugs. Therefore, the discovery of new drug candidates that could effectively eradicate cancer stem cells afforded promising outcomes in cancer therapy.
Objective: Natural products and their synthetic analogues are a rich source of biologically active compounds and several of them have already been recognized as potent CSCs killers. We aim to provide a collection of recently identified natural products that suppressed the survival of the small invasive CSC populations and combated the drug resistance of these cells in chemotherapy.
Results: These anti-CSCs natural products included flavonoids, stilbenes, quinones, terpenoids, polyketide antibiotics, steroids and alkaloids. In the present review, we highlighted the therapeutic potential of natural products and their derivatives against the proliferation and drug resistance of CSCs, their working mechanisms and related structure- activity relationships.
Conclusion: Meanwhile, in this survey, several natural products with diverse cellular targets such as the naphthoquinone shikonin and the stilbene resveratrol were characterized as promising lead compounds for future development.
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Cite this article as:
Natural Products Targeting Cancer Stem Cells: A Revisit, Current Medicinal Chemistry 2021; 28 (33) . https://dx.doi.org/10.2174/0929867328666210405111913
DOI https://dx.doi.org/10.2174/0929867328666210405111913 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |

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