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Current Diabetes Reviews

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ISSN (Print): 1573-3998
ISSN (Online): 1875-6417

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Meta-Analysis

Effect of Yoga on Oxidative Stress in Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis

Author(s): V. Venugopal, S. Geethanjali, S. Poonguzhali, R. Padmavathi, S. Mahadevan, S. Silambanan and K. Maheshkumar*

Volume 18, Issue 2, 2022

Published on: 05 April, 2021

Article ID: e050421192663 Pages: 8

DOI: 10.2174/1573399817666210405104335

Price: $65

Abstract

Background: Diabetes mellitus has a significant impact on public health. Oxidative stress plays a major role in the pathophysiology of Type 2 Diabetes Mellitus (T2DM), leading to various complications of T2DM. Yoga is being widely used in the management of T2DM. The primary objective of this systematic review and meta-analysis is to understand the effects of yoga on oxidative stress parameters among adult patients diagnosed with T2DM.

Materials and Methods: Electronic databases such as PubMed, Scopus, Cochrane Library and Science Direct from start of the study till March 2020 were searched to obtain eligible studies. Study designs of all nature were included (except case studies and reviews). The primary outcome was Malondialdehyde (MDA) and secondary outcomes included fasting plasma glucose, HbA1C and Superoxide Dismutase (SOD) levels.

Results: A total of four trials with a total of 440 patients met the inclusion criteria. The results of meta-analysis indicated that yoga significantly reduced MDA (SMD: -1.4; 95% CI -2.66 to -0.13; P = 0.03; I2 = 97%), fasting plasma glucose levels (SMD: -1.87: 95% CI -3.83 to -0.09; P = 0.06; I2= 99%), and HbA1c (SMD: -1.92; 95% CI - 3.03 to -0.81; P = 0.0007; I2 = 92%) in patients with T2DM. No such effect was found for SOD (SMD: -1.01; 95% CI -4.41 to 2.38; P = 0.56; I2= 99%).

Conclusion: The available evidence suggests that yoga reduces MDA, fasting plasma glucose and HbA1C, and thus would be beneficial in the management of T2DM as a complementary therapy. However, considering the limited number of studies and its heterogeneity, further robust studies are necessary to strengthen our findings and investigate the long-term benefits of yoga.

Keywords: Type 2 diabetes mellitus, yoga, oxidative stress, malondialdehyde, public health, inflammation disorder.

[1]
Colosia AD, Palencia R, Khan S. Prevalence of hypertension and obesity in patients with type 2 diabetes mellitus in observational studies: a systematic literature review. Diabetes Metab Syndr Obes 2013; 6: 327-38.
[http://dx.doi.org/10.2147/DMSO.S51325] [PMID: 24082791]
[2]
DeFronzo RA, Ferrannini E, Groop L, et al. Type 2 diabetes mellitus. Nat Rev Dis Primers 2015; 1(1): 15019.
[http://dx.doi.org/10.1038/nrdp.2015.19] [PMID: 27189025]
[3]
Liu C, Feng X, Li Q, Wang Y, Li Q, Hua M. Adiponectin, TNF-α and inflammatory cytokines and risk of type 2 diabetes: A systematic review and meta-analysis. Cytokine 2016; 86: 100-9.
[http://dx.doi.org/10.1016/j.cyto.2016.06.028] [PMID: 27498215]
[4]
Folli F, Corradi D, Fanti P, et al. The role of oxidative stress in the pathogenesis of type 2 diabetes mellitus micro- and macrovascular complications: avenues for a mechanistic-based therapeutic approach. Curr Diabetes Rev 2011; 7(5): 313-24.
[http://dx.doi.org/10.2174/157339911797415585] [PMID: 21838680]
[5]
Asmat U, Abad K, Ismail K. Diabetes mellitus and oxidative stress-A concise review. Saudi Pharm J 2016; 24(5): 547-53.
[http://dx.doi.org/10.1016/j.jsps.2015.03.013] [PMID: 27752226]
[6]
Kohnert K-D, Freyse E-J, Salzsieder E. Glycaemic variability and pancreatic β-cell dysfunction. Curr Diabetes Rev 2012; 8(5): 345-54.
[http://dx.doi.org/10.2174/157339912802083513] [PMID: 22698079]
[7]
Volpe CMO, Villar-Delfino PH, Dos Anjos PMF, Nogueira- Machado JA. Cellular death, reactive oxygen species (ROS) and diabetic complications. Cell Death Dis 2018; 9(2): 119.
[http://dx.doi.org/10.1038/s41419-017-0135-z] [PMID: 29371661]
[8]
Gupta M, Chari S. Proxidant and antioxidant status in patients of type II Diabetes Mellitus with IHD. Indian J Clin Biochem 2006; 21(2): 118-22.
[http://dx.doi.org/10.1007/BF02912925] [PMID: 23105627]
[9]
Gunawardena HP, Silva R, Sivakanesan R, Ranasinghe P, Katulanda P. Poor glycaemic control is associated with increased lipid peroxidation and glutathione peroxidase activity in type 2 diabetes patients. Oxid Med Cell Longev 2019; 2019: 9471697.
[http://dx.doi.org/10.1155/2019/9471697]
[10]
Shafi S, Ansari HR, Bahitham W, Aouabdi S. The impact of natural antioxidants on the regenerative potential of vascular cells. Front Cardiovasc Med 2019; 6: 28.
[http://dx.doi.org/10.3389/fcvm.2019.00028] [PMID: 30968031]
[11]
Gordon LA, Morrison EY, McGrowder DA, et al. Effect of exercise therapy on lipid profile and oxidative stress indicators in patients with type 2 diabetes. BMC Complement Altern Med 2008; 8(1): 21.
[http://dx.doi.org/10.1186/1472-6882-8-21] [PMID: 18477407]
[12]
Tvrdá E, Benko F. Free radicals: What they are and what they do.Pathology. Elsevier 2020; pp. 3-13.
[http://dx.doi.org/10.1016/B978-0-12-815972-9.00001-9]
[13]
Prentki M, Nolan CJ. Islet β cell failure in type 2 diabetes. J Clin Invest 2006; 116(7): 1802-12.
[http://dx.doi.org/10.1172/JCI29103] [PMID: 16823478]
[14]
Omoruyi F, Sparks J, Stennett D, Dilworth L. Superoxide dismutase as a measure of antioxidant status and its application to diabetes. Academic Press, Elsevier 2020; pp. 409-17.
[http://dx.doi.org/10.1016/B978-0-12-815776-3.00041-3]
[15]
Aramata S, Han S-I, Kataoka K. Roles and regulation of transcription factor MafA in islet β-cells. Endocr J 2007; 54(5): 659-66.
[http://dx.doi.org/10.1507/endocrj.KR-101] [PMID: 17785922]
[16]
Baeyens N, Bandyopadhyay C, Coon BG, Yun S, Schwartz MA. Endothelial fluid shear stress sensing in vascular health and disease. J Clin Invest 2016; 126(3): 821-8.
[http://dx.doi.org/10.1172/JCI83083] [PMID: 26928035]
[17]
Simioni C, Zauli G, Martelli AM, et al. Oxidative stress: Role of physical exercise and antioxidant nutraceuticals in adulthood and aging. Oncotarget 2018; 9(24): 17181-98.
[http://dx.doi.org/10.18632/oncotarget.24729] [PMID: 29682215]
[18]
Olesen J, Gliemann L, Biensø R, Schmidt J, Hellsten Y, Pilegaard H. Exercise training, but not resveratrol, improves metabolic and inflammatory status in skeletal muscle of aged men. J Physiol 2014; 592(8): 1873-86.
[http://dx.doi.org/10.1113/jphysiol.2013.270256] [PMID: 24514907]
[19]
Venugopal V, Rathi A, Raghuram N. Effect of short-term yoga-based lifestyle intervention on plasma glucose levels in individuals with diabetes and pre-diabetes in the community. Diabetes Metab Syndr 2017; 11(Suppl. 2): S597-9.
[http://dx.doi.org/10.1016/j.dsx.2017.04.010] [PMID: 28420577]
[20]
Maheshkumar K, Venugopal V, Poonguzhali S, Mangaiarkarasi N, Venkateswarane ST, Manavalan N. Trends in the use of Yoga and Naturopathy based lifestyle clinics for the management of Non-communicable diseases (NCDs) in Tamilnadu, South India. Clin Epidemiol Glob Health 2020; 8(2): 647-51.
[http://dx.doi.org/10.1016/j.cegh.2019.09.013]
[21]
Vijayakumar V, Mavathur R, Raguram N, Ranjani H, Anjana RM, Mohan V. Potential role of yoga in management of the ominous octet: Adding a new facet to type 2 diabetes management and prevention. J Diab 2020; 12(1): 10.
[22]
Vijayakumar V, Mavathur R, Sharma MNK, Kannan S. Reduced glycemic variability with yoga in patients with type 2 diabetes mellitus: Results of a pilot study. J Diabetes Sci Technol 2019; 13(4): 803-4.
[http://dx.doi.org/10.1177/1932296819852064] [PMID: 31137967]
[23]
Ross A, Thomas S. The health benefits of yoga and exercise: A review of comparison studies. J Altern Complement Med 2010; 16(1): 3-12.
[http://dx.doi.org/10.1089/acm.2009.0044] [PMID: 20105062]
[24]
Moher D, Liberati A, Tetzlaff J, Altman DG. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. PLoS Med 2009; 6(7): e1000097.
[http://dx.doi.org/10.1371/journal.pmed.1000097] [PMID: 19621072]
[25]
Viera AJ, Garrett JM. Understanding interobserver agreement: The kappa statistic. Fam Med 2005; 37(5): 360-3.
[PMID: 15883903]
[26]
Luchini C, Solmi M, Stubbs B, Veronese N. Assessing the quality of studies in meta-analyses: Advantages and limitations of the newcastle ottawa scale. World J Metaanal 2017; 5(4): 80-4.
[http://dx.doi.org/10.13105/wjma.v5.i4.80]
[27]
Hegde SV, Adhikari P, Kotian SM, Shastry R. Effects of yoga versus sham yoga on oxidative stress, glycemic status, and anthropometry in type 2 diabetes mellitus: A single-blinded randomized pilot study. Int J Yoga Therap 2020; 30(1): 33-9.
[PMID: 31283365]
[28]
Hegde SV, Adhikari P, Kotian S, Pinto VJ, D’Souza S, D’Souza V. Effect of 3-month yoga on oxidative stress in type 2 diabetes with or without complications: A controlled clinical trial. Diabetes Care 2011; 34(10): 2208-10.
[http://dx.doi.org/10.2337/dc10-2430] [PMID: 21836105]
[29]
Hegde SV, Adhikari P, Subbalakshmi NK, Nandini M, Rao GM, D’Souza V. Diaphragmatic breathing exercise as a therapeutic intervention for control of oxidative stress in type 2 diabetes mellitus. Complement Ther Clin Pract 2012; 18(3): 151-3.
[http://dx.doi.org/10.1016/j.ctcp.2012.04.002] [PMID: 22789789]
[30]
Ramamoorthi R, Gahreman D, Moss S, Skinner T. The effectiveness of yoga to prevent diabetes mellitus type 2: A protocol for systematic review and meta-analysis. Medicine (Baltimore) 2019; 98(3): e14019.
[http://dx.doi.org/10.1097/MD.0000000000014019] [PMID: 30653107]
[31]
Cramer H, Lauche R, Langhorst J, Dobos G. Are Indian yoga trials more likely to be positive than those from other countries? A systematic review of randomized controlled trials. Contemp Clin Trials 2015; 41: 269-72.
[http://dx.doi.org/10.1016/j.cct.2015.02.005] [PMID: 25705015]
[32]
Cramer H, Lauche R, Haller H, Steckhan N, Michalsen A, Dobos G. Effects of yoga on cardiovascular disease risk factors: A systematic review and meta-analysis. Int J Cardiol 2014; 173(2): 170-83.
[http://dx.doi.org/10.1016/j.ijcard.2014.02.017] [PMID: 24636547]

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