摘要
金纳米团簇(AuNCs)作为一种新型纳米材料,具有斯托克斯位移大、制备相对简单、水溶性好、毒性低、生物相容性好等许多特殊的理化性质,使其在各种应用中展现出无限的潜力。 领域,尤其是癌症治疗领域。 近年来,AuNCs的制备、功能化和生物医学应用取得了很大进展。 本文总结了AuNCs的最新研究进展和合成方法,强调采用“自下而上”的合成策略进行制备。 此外,我们介绍了 AuNCs 的体内药代动力学性能。 在最后一部分,我们举例说明了AuNCs在生物医学中的应用,包括光热疗法(PTT)、生物成像、药物递送和放疗增敏,进一步证实了AuNCs在肿瘤治疗中的巨大潜力。
关键词: 金纳米团簇、药代动力学、光热疗法、生物成像、药物输送、放射增敏剂。
Current Medicinal Chemistry
Title:Preparation, Pharmacokinetic and Application of Gold Nanoclusters (AuNCs) in Tumor Treatment
Volume: 28 Issue: 34
关键词: 金纳米团簇、药代动力学、光热疗法、生物成像、药物输送、放射增敏剂。
摘要: As a new type of nanomaterials, the gold nanoclusters (AuNCs) perform many special physical and chemical properties, such as large Stokes shift, relatively simple preparation, good water solubility, low toxicity, and good biocompatibility, which make them show infinite potential in various fields, especially in cancer treatment. In recent years, great progress has been made in the preparation, functionalization, and biomedical applications of the AuNCs. In this article, the latest research progress and synthesis methods of the AuNCs have been summarized, emphasizing the preparation using the “bottom- up” synthesis strategy. Furthermore, we introduced the in vivo pharmacokinetic performance of the AuNCs. In the last part, we exemplified the applications of the AuNCs in biomedicine, including photothermal therapy (PTT), bioimaging, drug delivery, and radiotherapy sensitization, which further confirmed the great potential of the AuNCs in tumor treatment.
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Cite this article as:
Preparation, Pharmacokinetic and Application of Gold Nanoclusters (AuNCs) in Tumor Treatment, Current Medicinal Chemistry 2021; 28 (34) . https://dx.doi.org/10.2174/0929867328666210331145134
DOI https://dx.doi.org/10.2174/0929867328666210331145134 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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