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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Research Article

一种有效的AD和aMCI脑成像生物标志物:Slow-5频带ALFF

卷 18, 期 1, 2021

发表于: 24 March, 2021

页: [45 - 55] 页: 11

弟呕挨: 10.2174/1567205018666210324130502

价格: $65

摘要

背景：低频波动振幅(ALFF)作为一种潜在的脑成像生物标志物，已被用于区分阿尔茨海默病(AD)和失忆性轻度认知障碍(aMCI)患者与正常对照(NC)患者。然而，目前尚不清楚ALFF改变的频率依赖模式是否能有效区分疾病的不同阶段。 方法：本研究共纳入AD患者52例，aMCI患者50例，NC患者43例。ALFF值在以下三个频段进行计算:classical (0.01-0.08 Hz)， slow-4 (0.027-0.073 Hz)， slow-5 (0.01-0.027 Hz)。随后，以局部功能异常为特征，采用支持向量机(SVM)检测AD、aMCI和NC的分类效果。 结果：我们发现ALFF在不同频带的组间差异主要位于左侧海马(HP)、右侧海马(HP)、双侧扣带回(PCC)和双侧楔前叶(PCu)、左侧角回(AG)和左侧内侧前额叶皮层(mPFC)。当以局部功能异常为特征时，我们发现ALFF在slow-5频段区分三组的准确率最高。 结论：这些发现可能加深我们对AD发病机制的认识，提示slow-5频带可能有助于探讨AD的发病机制和分期。

关键词: 阿尔茨海默病，失忆性轻度认知障碍，静息状态功能性磁共振成像，低频波动幅度，slow-5频带，支持向量机

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