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General Review Article

耐甲氧西林金黄色葡萄球菌 (MRSA) 丙酮酸激酶 (PK) 抑制剂及其抗菌活性

卷 29, 期 5, 2022

发表于: 22 March, 2021

页: [908 - 923] 页: 16

弟呕挨: 10.2174/0929867328666210322103340

价格: $65

摘要

医疗保健和社区环境中已经存在对抗生素的耐药性。 因此，开发新型抗生素迫在眉睫。 耐甲氧西林金黄色葡萄球菌 (MRSA) 丙酮酸激酶 (PK) 对细菌的存活至关重要，使其成为一种新的抗菌靶点。 近十年来，最常报道的PK抑制剂包括天然产物小分子或其类似物的吲哚、黄酮、吩嗪衍生物或虚拟筛选小分子化合物库。 本综述涵盖了 2011 年初至 2020 年年中报告的 PK 抑制剂及其抗菌活性。 还简要讨论了构效关系 (SAR)。

关键词: 耐甲氧西林金黄色葡萄球菌、丙酮酸激酶抗菌素、腙类、吲哚类、黄酮类、硝基化合物、吩嗪类。

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