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Current Molecular Pharmacology

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ISSN (Print): 1874-4672
ISSN (Online): 1874-4702

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General Review Article

Anticancer Effects of Ginsenoside Rh2: A Systematic Review

Author(s): Xin-Ling He, Xiao-Huang Xu, Jia-Jie Shi, Mingqing Huang, Yitao Wang, Xiuping Chen and Jin-Jian Lu*

Volume 15, Issue 1, 2022

Published on: 09 March, 2021

Article ID: e040122192163 Pages: 11

DOI: 10.2174/1874467214666210309115105

Price: $65

Abstract

Background: As one of the effective pharmacological constituents of Ginseng Radix et Rhizoma, ginsenoside Rh2 (Rh2) exerts a remarkable anticancer effect on various cancer cell lines in vitro and strongly inhibits tumor growth in vivo without severe toxicity.

Objective: This article reviewed existing evidence supporting the anticancer effects of Rh2 to classify and conclude previous and current knowledge on the mechanisms and therapeutic effects of Rh2, as well as to promote the clinical application of this natural product.

Conclusion: This article reviewed the anticancer efficacies and mechanisms of Rh2, including the induction of cell cycle arrest and programmed cell death, repression of metastasis, alleviation of drug resistance, and regulation of the immune system. Finally, this paper discussed the research and application prospects of Rh2.

Keywords: Ginseng, ginsenoside Rh2, cancer, cytotoxicity, mechanism, natural compound

Graphical Abstract

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