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当代肿瘤药物靶点

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Research Article

姜黄素类似物 EF24 对化疗耐药的黑色素瘤细胞具有高度活性

卷 21, 期 7, 2021

发表于: 03 March, 2021

页: [608 - 618] 页: 11

弟呕挨: 10.2174/1568009621666210303092921

价格: $65

摘要

背景：由于恶性黑色素瘤（MM） 细胞对化疗无反应，MM 是一种预后较差的侵袭性皮肤癌。 目的：在本研究中，我们评估了几种姜黄素类似物对四种 MM 细胞系（SK-MEL-28、MeWo、A-375 和 CHL-1）的有效性，并探讨了它们的潜在作用机制。 方法：通过基于四唑的 MTS 测定法测量细胞活力。通过流式细胞术检测细胞凋亡、活性氧 (ROS) 和细胞周期。通过蛋白质印迹分析蛋白质水平。 结果：MM细胞对常规化疗药物顺铂和达卡巴嗪以及靶向治疗药物威罗非尼具有很强的抗性。在姜黄素类似物中，EF24 是对抗耐药性 MM 细胞最有效的化合物。 EF24 剂量和时间依赖性地通过诱导细胞凋亡降低 MM 细胞的活力。虽然 EF24 没有增加活性氧 (ROS) 的产生，但它上调了内质网 (ER) 应激标记 BiP，但下调了未折叠蛋白反应 (UPR) 信号。此外，用 EF24 处理 MM 细胞会下调抗凋亡蛋白 Bcl-2 以及已知可保护 MM 细胞免于凋亡的凋亡蛋白抑制剂 (IAP) XIAP、cIAP1 和 Birc7 的表达。 EF24 下调 Bcl-2 和 IAP 表达与抑制 NF-κB 通路有关。 结论：这些发现表明 EF24 是一种有效的抗 MM 剂。 抗 MM 效应可能是由抑制 UPR 和 NF-κB 通路介导的。

关键词: Bcl-2、EF24、IAP、恶性黑色素瘤、NF-κB、未折叠蛋白反应。

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