Abstract
A largely historical survey is presented on the development of methods for the synthesis of oligonucleotides containing either 3??-S- or 5??-S-phosphorothiolate linkages. The properties of these modifications are discussed with emphasis on their specific cleavage and the use of a metal ion specificity switch for investigating the role of metal ions in enzyme- catalysed DNA/RNA cleavage processes. Finally, the effect of the 3??-S-phosphorothiolate modification on the structure of nucleic acids is described.
Current Organic Chemistry
Title: Synthesis, Properties and Application of Nucleic Acids Containing Phosphorothiolate Linkages
Volume: 12 Issue: 4
Author(s): Richard Cosstick and James W. Gaynor
Affiliation:
Abstract: A largely historical survey is presented on the development of methods for the synthesis of oligonucleotides containing either 3??-S- or 5??-S-phosphorothiolate linkages. The properties of these modifications are discussed with emphasis on their specific cleavage and the use of a metal ion specificity switch for investigating the role of metal ions in enzyme- catalysed DNA/RNA cleavage processes. Finally, the effect of the 3??-S-phosphorothiolate modification on the structure of nucleic acids is described.
Export Options
About this article
Cite this article as:
Cosstick Richard and Gaynor W. James, Synthesis, Properties and Application of Nucleic Acids Containing Phosphorothiolate Linkages, Current Organic Chemistry 2008; 12 (4) . https://dx.doi.org/10.2174/138527208783743769
DOI https://dx.doi.org/10.2174/138527208783743769 |
Print ISSN 1385-2728 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5348 |
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
Chemistry and Biology of Carbohydrates
Carbohydrates are one of the most abundant natural products and are considered to be extremely important biomolecules for their ever-increasing impact on chemistry and biology. Their role in several important biological processes, notably energy storage, transport, modulation of protein function, intercellular adhesion, malignant transformation, signal transduction, viral, and bacterial cell ...read more
Related Journals
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements