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Current Organic Chemistry

Editor-in-Chief

ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

Chemical Strategies for Oligonucleotide-Conjugates Synthesis

Author(s): E. Defrancq, Y. Singh and N. Spinelli

Volume 12, Issue 4, 2008

Page: [263 - 290] Pages: 28

DOI: 10.2174/138527208783743732

Price: $65

Abstract

Oligonucleotide conjugates have found numerous applications in the field of diagnostics and therapeutics. Structurally diverse oligonucleotide conjugates have been prepared and evaluated for various applications. Research efforts have focused on the development of synthetic procedures to accomplish efficient oligonucleotide conjugation with different target molecules. Both on-support and solution-phase coupling procedures have been used to conjugate oligonucleotides. This review gives an account of major synthetic approaches available to prepare covalent oligonucleotide conjugates with diverse target molecules.


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