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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Research Article

七氟醚而不是异丙酚在人神经母细胞瘤SH-SY5Y细胞中提供细胞存活的双重作用

卷 17, 期 14, 2020

页: [1311 - 1319] 页: 9

弟呕挨: 10.2174/1567205018666210218162856

价格: $65

摘要

背景：我们假设最常用的静脉（丙泊酚）和吸入（七氟醚）全身麻醉药会影响细胞存活浓度和持续时间，并依赖于其影响细胞内Ca + 2稳态的不同潜能而具有不同的潜能。 方法：用野生型或M146L突变型人早老素1稳定转染的人神经母细胞瘤SH-SY5Y细胞进行培养，并使其与异丙酚或七氟醚等效。测量细胞活力，细胞溶质和线粒体钙。 结果：在临床相关浓度和持续时间下，七氟醚而非丙泊酚可促进细胞存活。 1％七氟醚的长时间暴露（24小时）导致两种类型的细胞均受到明显的细胞损害。在细胞外钙存在的情况下，七氟醚和异丙酚对细胞质Ca + 2或线粒体Ca + 2升高的细胞反应率均显着较高。由于Ca + 2的流入，七氟醚而不是等价的1 MAC丙泊酚导致阿尔茨海默氏病突变细胞的峰和总Ca + 2的增加明显大于野生型细胞，但线粒体Ca + 2的总浓度增加更多在野生型中比突变细胞。在不存在细胞外Ca + 2流入的情况下，七氟醚而非丙泊酚引起突变细胞中线粒体Ca + 2总体浓度的升高比对照细胞更为明显。 结论：钙的大量流入介导了全身麻醉药介导的细胞质或线粒体Ca + 2的升高，尤其是异丙酚。七氟醚比丙泊酚具有更高的促进或抑制细胞存活的能力，这可能与其影响细胞溶质或线粒体Ca + 2浓度的能力有关。

关键词: 麻醉药，阿尔茨海默氏病，钙，神经退行性疾病，细胞凋亡，细胞死亡。

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