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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Research Article

每天8分钟的高强度间歇训练对大鼠Aβ1-42阿尔茨海默病模型的神经保护作用

卷 17, 期 14, 2020

页: [1320 - 1333] 页: 14

弟呕挨: 10.2174/1567205018666210218161856

价格: $65

摘要

背景：阿尔茨海默氏病（AD）是最常见且不可逆的神经退行性疾病，淀粉样蛋白肽在其发病机理中起着核心作用。体育锻炼是对AD的有益适应。但是，由于许多文献在整个方案中都使用了固定的训练处方变量（强度和量），因此这些作用可能被低估了。此外，研究人员很少了解慢性高强度间歇训练（HIIT）是否对AD个体的脑组织产生类似的作用。 目的：本研究评估了AD模型中8分钟的HIIT伴随递增过载的效果。 方法：将40只Wistar雄性大鼠分为四组：未训练的Sham组，Sham训练组，Aβ1-42（Alzheimer''s）未训练组和Aβ1-42（Alzheimer''s）训练组（每组10只大鼠）。动物接受了立体定向手术，并接受了海马注射的Aβ1-42或盐溶液。手术后7天，进行了两周的跑步机适应性训练，然后进行了最大跑步测试（MRT）。然后，对动物进行HIIT八周。行为测试（开阔地域和Morris水迷宫）后24小时处死大鼠，提取海马组织以分析氧化还原平衡和BDNF / TrkB途径，并通过评估银的浸渍来检测神经营养斑块（NP）。 结果：经过AD训练的组每两周出现一次体力改善，运动，学习和记忆能力得到改善（p <0.05）。这些影响伴随着CAT和SOD含量的增加，接着是脂质过氧化作用的降低（p <0.05）。此外，观察到BDNF / TrkB途径的激活增加（p <0.05），NP降低。 结论：基于这些结果，MRT对于出色的慢性训练方案处方和超负荷调整至关重要。因此，每天8分钟的HIIT，持续8周，可以通过促进正的氧化还原平衡和增加BDNF / TrkB途径的活性（可能有助于NP衰减）来减少行为缺陷。

关键词: 神经退行性疾病，痴呆，治疗，HIIT，定期训练，强度运动。

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