Heme Oxygenase: A Target Gene for Anti-Diabetic and Obesity

Title: Heme Oxygenase: A Target Gene for Anti-Diabetic and Obesity

Volume: 14 Issue: 5

Author(s): N. G. Abraham, P. L. Tsenovoy, J. McClung and G. S. Drummond

Affiliation:

Keywords: Diabetes, Carbon monoxide, bilirubin, HO-1, Inflamation, TNF, IL-1, adiponectin

Abstract: Heme oxygenase-1 (HO-1) is central to the regulation of oxidative injury. The role of increased HO-1 expression and Heme oxygenase (HO) activity in mitigating the detrimental side effect of diabetes is examined. A review of the mechanism(s) of action is included. This may lead to the development of pharmacological and genetic approaches to mitigate the clinical complications associated with the progression of diabetes and obesity.

Cite this article as:

Abraham G. N., Tsenovoy L. P., McClung J. and Drummond S. G., Heme Oxygenase: A Target Gene for Anti-Diabetic and Obesity, Current Pharmaceutical Design 2008; 14 (5) . https://dx.doi.org/10.2174/138161208783597371