摘要
热休克蛋白 (HSPs) 作为蛋白质稳定的分子伴侣发挥着重要作用。小 HSP 是一组 12-43 kDa 范围内的低分子量 HSP,被归类为 HSPB。在该家族的十个成员中,HSPB1(HSP27)、HSPB5(αB-晶状体蛋白)、HSPB6(HSP20)和 HSPB8(HSP22)普遍存在于各种组织中,包括肝组织。这些小的 HSP 作为翻译后修饰进行磷酸化,并且它们的功能受到调节。肝细胞癌(HCC)是最常见的癌症之一,也是全球癌症相关死亡的第四大原因。 HSP作为分子伴侣发挥细胞保护作用。因此,HSPB通常被认为可以保护HCC细胞并帮助HCC的进展。另一方面,我们实验室最近的研究表明磷酸化 HSPB1、HSPB6 和 HSPB8 在 HCC 进展中的抑制作用。这些发现可能为 HSPB 针对 HCC 进展的新型防御系统提供基础。本综述重点关注 HSPB 在 HCC 中的细胞功能并总结了目前的研究。
关键词: 小HSP、HSPB、HCC、细胞凋亡、增殖、转移。
Current Molecular Medicine
Title:Cellular Functions of Small Heat Shock Proteins (HSPB) in Hepatocellular Carcinoma
Volume: 21 Issue: 10
关键词: 小HSP、HSPB、HCC、细胞凋亡、增殖、转移。
摘要: Heat shock proteins (HSPs) play an essential role as molecular chaperones in proteostasis. Small HSPs are a group of low-molecular-weight HSPs in the range of 12- 43 kDa and are classified as HSPB. Within the ten members of the family, HSPB1(HSP27), HSPB5 (αB-crystallin), HSPB6 (HSP20), and HSPB8 (HSP22) ubiquitously exist in various tissues, including liver tissue. These small HSPs undergo phosphorylation as a post-translational modification, and their functions are modulated. Hepatocellular carcinoma (HCC) is one of the most frequent cancers and the fourth leading cause of cancer-related death worldwide. HSPs play a cytoprotective role as molecular chaperones. Thus, HSPB has been generally considered to protect HCC cells and help the progression of HCC. On the other hand, recent studies from our laboratories have demonstrated suppressive roles of phospho-HSPB1, HSPB6, and HSPB8 in the progression of HCC. These findings may provide a basis for a novel defense system by HSPB against HCC progression. This review focuses on the cellular functions of HSPB in HCC and summarizes the current research.
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Cellular Functions of Small Heat Shock Proteins (HSPB) in Hepatocellular Carcinoma, Current Molecular Medicine 2021; 21 (10) . https://dx.doi.org/10.2174/1573405617666210204211252
DOI https://dx.doi.org/10.2174/1573405617666210204211252 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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