摘要
生物可降解纳米颗粒 (NPs) 由于其可接受的生物利用度、较低的毒性、封装和控制释放的效力而具有多种用作药物递送载体的用途。此外,NPs 与网状内皮系统 (RES) 巨噬细胞的相互作用可能会降低 NPs 的医疗功效。纳米颗粒的表面通常用聚乙二醇(PEG)等分子中和,其为应用最广泛的隐形聚合物之一,以限制纳米颗粒通过 RES 系统的清除。事实上,这些分子表现出对 RES 清除和蛋白质吸附的抵抗力。不幸的是,修改 PEG 有一些缺点,如合成问题以及与免疫反应的相关性。 CD47 受体是众所周知的自身细胞表面的“不要吃我”分子。因此,受体将通过与其配体(称为信号调节蛋白 α (SIRP-α))结合来抑制吞噬作用。此外,CD47受体作为仿生物质之一或其衍生肽,最近已被用于纳米颗粒表面,以抑制吞噬作用并增加纳米颗粒在血液循环中的保留时间。因此,本综述研究检查了 CD47 受体及其在免疫系统中的作用,以及 CD47 受体在包覆纳米粒以增加其在血液循环中的保留时间的用途。
关键词: CD47,纳米颗粒,聚乙二醇,吞噬作用,SIRP-α,网状内皮系统。
图形摘要
Current Drug Targets
Title:CD47 Functionalization of Nanoparticles as a Poly(ethylene glycol) Alternative: A Novel Approach to Improve Drug Delivery
Volume: 22 Issue: 15
关键词: CD47,纳米颗粒,聚乙二醇,吞噬作用,SIRP-α,网状内皮系统。
摘要:
Bio-degradable nanoparticles (NPs) have several utilizations as drug delivery vehicles due to their acceptable bio-availability, lower toxicity, potency for encapsulation and controlled release. Moreover, the interaction of the NPs with the macrophages of the reticuloendothelial system (RES) may decrease NPs efficacy for medical purposes. The surface of NPs is conventionally neutralized with the molecules such as poly(ethylene glycol) (PEG), as one of the most widely applied stealth polymers, in order to restrict the NPs clearance through the RES system. In fact, these molecules exhibit resistance to RES clearance and protein adsorption. It is unfortunate that modifying the PEG has some shortcomings, like problems in the synthesis as well as correlation to the immune reaction. The CD47 receptor has been well known as a ‘don’t-eat-me’ molecule on the self-- cells' surface. Therefore, the receptor will inhibit phagocytosis via binding to its ligand that is known as the signal regulatory protein α (SIRP-α). Moreover, the CD47 receptor, as one of the biomimetic substances, or its derivative peptides, have been used recently on the surface of nanoparticles to inhibit phagocytosis and increase the NPs retention time in the blood circulation.
Therefore, this review study examined the CD47 receptor and its role in the immune system as well as the use of the CD47 receptor in coating NPs to increase their retention time in the blood circulation.
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Cite this article as:
CD47 Functionalization of Nanoparticles as a Poly(ethylene glycol) Alternative: A Novel Approach to Improve Drug Delivery, Current Drug Targets 2021; 22 (15) . https://dx.doi.org/10.2174/1389450122666210204203514
DOI https://dx.doi.org/10.2174/1389450122666210204203514 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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