Abstract
This review deals with the synthetic methods, chemical reactions, and applications of triazolopyrimidine derivatives. The synthetic methods and chemical reactions are subdivided into groups according to the junction between triazole and pyrimidine moieties for instance [1,2,4]triazolo[1,5- a]pyrimidine, [1,2,4]triazolo[1,5-c]pyrimidine, [1,2,3]triazolo[1,5-a]pyrimidine, [1,2,3]triazolo[1,5- c]pyrimidine, [1,2,4]triazolo[4,3-c]pyrimidine, and [1,2,4]triazolo[4,3-a]pyrimidine. Pharmacological activity of triazolopyrimidins is also reported.
Keywords: Triazolopyrimidine, pyrimidine, triazole, synthesis, heterocycles, pharmacological activities.
Graphical Abstract
Mini-Reviews in Organic Chemistry
Title:Recent Trend in the Chemistry of Triazolopyrimidines and their Applications
Volume: 18 Issue: 8
Author(s): Mounir A. Salem, Mohamed S. Behalo and Rizk E. Khidre*
Affiliation:
- Chemistry Department, Faculty of Science, Jazan University, Jazan,Saudi Arabia
Keywords: Triazolopyrimidine, pyrimidine, triazole, synthesis, heterocycles, pharmacological activities.
Abstract: This review deals with the synthetic methods, chemical reactions, and applications of triazolopyrimidine derivatives. The synthetic methods and chemical reactions are subdivided into groups according to the junction between triazole and pyrimidine moieties for instance [1,2,4]triazolo[1,5- a]pyrimidine, [1,2,4]triazolo[1,5-c]pyrimidine, [1,2,3]triazolo[1,5-a]pyrimidine, [1,2,3]triazolo[1,5- c]pyrimidine, [1,2,4]triazolo[4,3-c]pyrimidine, and [1,2,4]triazolo[4,3-a]pyrimidine. Pharmacological activity of triazolopyrimidins is also reported.
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Cite this article as:
Salem A. Mounir , Behalo S. Mohamed and Khidre E. Rizk *, Recent Trend in the Chemistry of Triazolopyrimidines and their Applications, Mini-Reviews in Organic Chemistry 2021; 18 (8) . https://dx.doi.org/10.2174/1570193X18666210203155358
DOI https://dx.doi.org/10.2174/1570193X18666210203155358 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
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