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当代肿瘤药物靶点

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ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

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Review Article

Mad2 结合蛋白 p31comet 作为人类癌症治疗的潜在靶点

卷 21, 期 5, 2021

发表于: 28 January, 2021

页: [401 - 415] 页: 15

弟呕挨: 10.2174/1568009621666210129095726

价格: $65

摘要

纺锤体组装检查点 (SAC) 是一种监视机制，可防止在中期到后期过渡时有丝分裂退出，直到所有染色体都与纺锤体微管建立正确的双极连接。 SAC 的激活依赖于有丝分裂检查点复合体 (MCC) 的组装，这需要在未连接的动粒处从非活动的开放 Mad2 (OMad2) 到活动的封闭 Mad2 (C-Mad2) 的构象变化。 Mad2 结合蛋白 p31comet 通过促进 SAC 沉默、阻止 Mad2 激活和促进 MCC 分解，在控制及时有丝分裂退出方面发挥关键作用。 此外，越来越多的证据强调了 p31comet 作为癌症治疗靶点的潜力。 在这里，我们提供了 p31comet 在有丝分裂进展中的功能意义的最新概述，并讨论了 p31comet 在癌症和治疗策略中表达失调的潜力。

关键词: p31comet，有丝分裂，Mad2，纺锤体组装检查点，有丝分裂检查点复合体，癌症，治疗靶点。

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