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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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通过药理剂对细胞内Ca2 +含量进行微调-预防阿尔茨海默氏病海马神经元突触丢失的策略

卷 17, 期 12, 2020

页: [1065 - 1071] 页: 7

弟呕挨: 10.2174/1567205018666210119145735

价格: $65

摘要

阿尔茨海默氏病是老年痴呆症的主要形式。 如今，所有针对β-淀粉样蛋白的临床试验均未能表明β-淀粉样蛋白可能不是AD发病机制的病因。 因此，需要寻找替代方法来治疗AD患者。 神经元存储操纵的钙进入是调节细胞内Ca2 +含量的微调机制。 最近的证据表明，可通过药理药物靶向钙库操纵的钙通道，以防止突触丢失，恢复长期的增强作用和改变行为。 当前的小型评论讨论了通过靶向商店操纵的钙通道来调节细胞内钙失衡的基本化学结构及其作为抗AD药理剂的适用性。

关键词: 阿尔茨海默氏病，钙假说，nSOCE，药理剂，β-淀粉样蛋白，药理学。

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