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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Review Article

储存操作钙进入的影响：阿尔茨海默病神经退化的影响

卷 17, 期 12, 2020

页: [1088 - 1094] 页: 7

弟呕挨: 10.2174/1567205018666210119144241

价格: $65

摘要

阿尔茨海默氏病（AD）是一种隐性和进行性神经退行性疾病。中枢胆碱能神经元功能失调，淀粉样蛋白聚集和沉积，氧化应激和生物金属动态平衡已被认为是该毁灭性疾病的主要致病介质。但是，从这些假设得出的策略无法减慢或阻止AD的进展，从而需要针对多种病因因素或针对其他假设进行治疗的组合疗法。储库操作性钙进入（SOCE）是内质网（ER）内腔中钙耗竭导致钙跨质膜流入的过程。越来越多的证据表明，神经元SOCE（nSOCE）在AD家庭（FAD）中受到抑制，对其的抑制导致树突棘不稳定并增强淀粉样蛋白生成。早老素突变体不能充当ER钙泄漏通道，并促进ER钙传感器的基质相互作用分子（STIM）降解；这些影响可能解释了FAD中nSOCE的抑制。我们已经证明，自噬的激活会降解STIM蛋白，从而在蛋白酶体抑制和内质网应激（与AD密切相关）下对树突状乔木产生修整效果。因此，我们假设自噬通过降解STIM蛋白来抑制SOCE，从而导致AD中的突触丢失。本文将重点介绍SOCE在AD神经变性中的作用，STIM蛋白的降解机制以及治疗潜力和相关挑战。

关键词: 阿尔茨海默氏病，蛋白酶体抑制，内质网应激，钙，储库操作性钙进入，树突棘，基质相互作用分子，早老素，γ-分泌酶，ER钙库。

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