小分子HIV-1整合酶抑制剂的最新进展

Title:Recent Advances in Small-Molecule HIV-1 Integrase Inhibitors

Volume: 28 Issue: 24

关键词: 艾滋病，整合酶，HIV-1整合酶抑制剂，抗艾滋病药物，双抑制剂，变构整合酶抑制剂。

摘要: HIV-1 integrase catalyzed the insertion of viral DNA into the genome of human cells in the process of retrotranscription. Integrase is an attractive target for HIV-1 treatment due to the lack of its homologue in human cells and its vital role in HIV-1 replication. Although major progress in the development of HIV-1 integrase inhibitors has been made, some thorny problems, such as drug resistance, led to the further study of HIV-1 integrase inhibitors. This review briefly discussed the structure, function, and mechanism of catalysis of HIV-1 integrase and made a different conclusion for recent advances in small-molecule inhibitors of HIV-1 integrase.

Cite this article as:

Recent Advances in Small-Molecule HIV-1 Integrase Inhibitors, Current Medicinal Chemistry 2021; 28 (24) . https://dx.doi.org/10.2174/0929867328666210114124744