线粒体热休克蛋白和亲免蛋白在神经退行性疾病中的作用

Title:Role of Mitochondrial Heat-shock Proteins and Immunophilins in Neuro Degenerative Diseases

Volume: 22 Issue: 14

关键词: 亲免蛋白、神经变性、HSP90、FKBP51、FKBP52、亲环蛋白 A。

摘要: Pathophysiologic conditions of neurodegenerative diseases are unquestionably related to protein misfolding. The accumulation of misfolded proteins into relatively ordered structures such as fibrillar intracellular and extracellular amyloids results in tissue lesions that lead to neuronal loss and brain damage. In these pathologies, the occurrence of protein aggregates suggests certain inefficient or insufficient cellular responses of those molecular chaperones that should properly assist the folding of the client proteins. In this regard, most experimental models for neurodegenerative diseases have demonstrated that the overexpression of molecular chaperones provides effective neuroprotection. A subset of these molecular chaperones corresponds to a group of proteins that exhibit peptidylprolyl isomerase enzymatic activity, the immunophilins. Most of the family members of the latter group were first described as being responsible for the immunosuppressive response or they were reported as members of the chaperone complex associated with HSP90 in steroid receptor oligomers. In this article, we review some aspects of the liaison between molecular chaperones and neurodegenerative diseases, in particular heat-shock proteins and immunophilins with demonstrated influence on the proper function of mitochondria. This article is intended to address a field that represents a yet critical unmet clinical need for the development of neuroprotective molecules focused on potentially novel molecular targets.

Cite this article as:

Role of Mitochondrial Heat-shock Proteins and Immunophilins in Neuro Degenerative Diseases, Current Drug Targets 2021; 22 (14) . https://dx.doi.org/10.2174/1389450121999201230204320